Baseline levels, and changes over time in body mass index and fasting insulin, and their relationship to change in metabolic trait clustering.
Baseline levels, and changes over time in body mass index and fasting insulin, and their relationship to change in metabolic trait clustering.
复制标题
基线水平、体重指数和空腹胰岛素随时间的变化，以及它们与代谢特征聚类变化的关系。
DOI：
10.1089/met.2013.0148
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发表时间：
2014
影响因子：
2.1
通讯作者：
Meigs,JamesB
中科院分区：
文献类型：
--
作者：
Rutter,MartinK;Sullivan,LisaM;Fox,CarolineS;Wilson,PeterWF;Nathan,DavidM;Vasan,RamachandranS;D'AgostinoSr,RalphB;Meigs,JamesB
背景：在个体内发现多种代谢异常特征一起或“聚集”的频率比偶然预测的更高。肥胖和胰岛素抵抗(IR)对代谢性状聚集的单独和联合作用尚不确定。方法：在2,616名非糖尿病的弗雷明翰后代研究参与者中，体重指数和空腹胰岛素与个人内0-4代谢综合征特征(高血压、高甘油三酯、低高密度脂蛋白胆固醇、高血糖)的7年内变化有关。结果：在基线评估时，平均特性分数为1.4，7年平均特性分数变化为+0.25(0.02)特性，P<；0.0001。在只有BMI预测因素的模型中，基线BMI每五分之差，7年性状得分增加0.14个性状，而在7年随访期间，BMI每五分位数增加，性状得分增加0.3个性状。基线水平和空腹胰岛素的变化与特质分数的变化相似。在调整了年龄-性别-基线集群得分的模型中，特征得分的7年变化与基线BMI(0.07个性状)和空腹胰岛素(0.18个性状)均显著相关，与BMI(0.21个性状)和空腹胰岛素(0.18个性状)7年增量均为0.25%。结论：代谢性状聚集性的变化与基线水平以及BMI和空腹胰岛素的变化显著相关，这突显了肥胖和IR在代谢性状聚集性中的重要性。
Background:Multiple abnormal metabolic traits are found together or “cluster” within individuals more often than is predicted by chance. The individual and combined role of adiposity and insulin resistance (IR) on metabolic trait clustering is uncertain. We tested the hypothesis that change in trait clustering is a function of both baseline level and change in these measures.Methods:In 2616 nondiabetic Framingham Offspring Study participants, body mass index (BMI) and fasting insulin were related to a within-person 7-year change in a trait score of 0–4 Adult Treatment Panel III metabolic syndrome traits (hypertension, high triglycerides, low high-density lipoprotein cholesterol, hyperglycemia).Results:At baseline assessment, mean trait score was 1.4 traits, and 7-year mean (SEM) change in trait score was +0.25 (0.02) traits,P<0.0001. In models with BMI predictors only, for every quintile difference in baseline BMI, the 7-year trait score increase was 0.14 traits, and for every quintile increase in BMI during 7-year follow-up, the trait score increased by 0.3 traits. Baseline level and change in fasting insulin were similarly related to trait score change. In models adjusted for age–sex–baseline cluster score, 7-year change in trait score was significantly related to both a 1-quintile difference in baseline BMI (0.07 traits) and fasting insulin (0.18 traits), and to both a 1-quintile 7-year increase in BMI (0.21 traits) and fasting insulin (0.18 traits).Conclusions:Change in metabolic trait clustering was significantly associated with baseline levels and changes in both BMI and fasting insulin, highlighting the importance of both obesity and IR in the clustering of metabolic traits.