Developmental regulation of two 5S ribosomal RNA genes.
Developmental regulation of two 5S ribosomal RNA genes.
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DOI：
10.1126/science.3420414
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发表时间：
1988-09
期刊：
影响因子：
56.9
通讯作者：
Alan P. Wolffe;Donald D. Brown
中科院分区：
文献类型：
--
作者：
Alan P. Wolffe;Donald D. Brown
两种爪蟾5S RNA基因（卵母细胞型和体细胞型）的发育调控可以通过RNA聚合酶III引导转录起始的转录复合体中蛋白质-蛋白质和蛋白质- dna相互作用的稳定性差异来解释。在发育过程中，转录因子从卵母细胞5S RNA基因中分离，使其受到染色质组装的抑制。在相同的细胞中，体细胞5S RNA基因保持活性是因为它们的转录复合物是稳定的。
The developmental regulation of two kinds of Xenopus 5S RNA genes (oocyte and somatic types) can be explained by differences in the stability of protein-protein and protein-DNA interactions in a transcription complex that directs transcription initiation by RNA polymerase III. Dissociation of transcription factors from oocyte 5S RNA genes during development allows them to be repressed by chromatin assembly. In the same cells, somatic 5S RNA genes remain active because their transcription complexes are stable.