NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.
NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.
复制标题
DOI：
10.1093/sleep/25.6.626
复制
发表时间：
2002-09
期刊：
影响因子：
5.6
通讯作者：
A. Krystal;J. Edinger;W. Wohlgemuth;G. Marsh
中科院分区：
文献类型：
--
作者：
A. Krystal;J. Edinger;W. Wohlgemuth;G. Marsh
研究目的：确定睡眠脑电频谱是否与以下因素有关：1)与传统多导睡眠图(PSG)相比，持续性原发失眠(PPI)患者低估睡眠时间的程度；2)传统多导睡眠图(PSG)评分相对较长且低估睡眠时间相对较大的PPI受试者的睡眠主诉。设计比较PPI主观失眠者(与PSG相比总睡眠时间相对较长且相对低估睡眠时间)和客观失眠者(PSG总睡眠时间相对较短者)的REM和NREM睡眠脑电频谱与正常人的脑电频谱。我们还研究了这些指标与睡眠低估程度之间的相关性。此外，我们还确定了睡眠脑电指数与睡眠主诉的关系程度。设置杜克大学医学中心睡眠实验室。研究对象正常(N=20)、主观失眠(N=12)和客观失眠(N=18)受试者。干预N/A测量和结果与正常人相比，主观性失眠症患者的脑电活动降低，α、sigma和βNREM脑电活动增加，而客观失眠者则未见。这些结果对亚型标准的变化很有说服力。未发现对REM光谱指数的影响。增量较小的非REM脑电活动预示着所有受试者对睡眠时间的主观估计和PSG估计之间的偏差更大。对于主观性失眠症受试者，低频脑电活动减少而高频非快速眼动脑电活动升高与睡眠主诉有关。结论NREM脑电频谱指标可作为主观性失眠症患者睡眠主诉的生理学指标，并可反映睡眠中觉醒程度的增强。
STUDY OBJECTIVES To determine whether the frequency spectrum of the sleep EEG is a physiologic correlate of 1) the degree to which individuals with persistent primary insomnia (PPI) underestimate their sleep time compared with the traditionally scored polysomnogram (PSG) and 2) the sleep complaints in PPI subjects who have relatively long traditionally scored PSG sleep times and relatively greater underestimation of sleep time. DESIGN We compared EEG frequency spectra from REM and NREM sleep in PPI subjects subtyped as subjective insomnia sufferers (those with relatively long total sleep time and relative underestimation of sleep time compared with PSG), and objective insomnia sufferers (those with relatively short PSG total sleep time) with EEG frequency spectra in normals. We also studied the correlation between these indices and the degree of underestimation of sleep. Further, we determined the degree to which sleep EEG indexes related to sleep complaints. SETTING Duke University Medical Center Sleep Laboratory. PARTICIPANTS Normal (N=20), subjective insomnia (N=12), and objective insomnia (N=18) subjects. INTERVENTIONS N/A. MEASUREMENTS AND RESULTS Lower delta and greater alpha, sigma, and beta NREM EEG activity were found in the patients with subjective insomnia but not those with objective insomnia, compared with the normal subjects. These results were robust to changes in the subtyping criteria. No effects were found for REM spectral indexes. Less delta non- REM EEG activity predicted greater deviation between subjective and PSG estimates of sleep time across all subjects. For the subjective insomnia subjects, diminished low-frequency and elevated higher frequency non- REM EEG activity was associated with their sleep complaints. CONCLUSIONS NREM EEG frequency spectral indexes appear to be physiologic correlates of sleep complaints in patients with subjective insomnia and may reflect heightened arousal during sleep.