Fertilization defects in sperm from mice lacking fertilinβ
Fertilization defects in sperm from mice lacking fertilinβ
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DOI：
10.1126/science.281.5384.1857
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发表时间：
1998-09-18
期刊：
影响因子：
56.9
通讯作者：
Myles, DG
中科院分区：
文献类型：
--
作者：
Cho, CH;Bunch, DO;Myles, DG
Fertilin 是 ADAM 家族的成员，存在于哺乳动物精子的质膜上。来自携带受精素β的小鼠的精子被证明在精卵膜粘附、精卵融合、从子宫迁移到输卵管以及与卵子透明带的结合方面存在缺陷。卵子激活不受影响。结果与生育素在精卵质膜相互作用中的直接作用一致。生育素还可能在精子-透明带结合或输卵管迁移中发挥直接作用。或者，对这些功能的影响可能是由于精子发生过程中缺乏生育素活性造成的。
Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice tacking fertilin beta were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.