Peptide and steroid regulation of muscle degeneration in an insect.
Peptide and steroid regulation of muscle degeneration in an insect.
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昆虫肌肉退化的肽和类固醇调节。
DOI：
10.1126/science.6278594
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Truman,JW
中科院分区：
文献类型：
--
作者：
Schwartz,LM;Truman,JW
巨型蚕蛾Antheraea polyphemus 的节间肌肉中发生两种类型的细胞死亡。第一个是纤维缓慢萎缩的结果，第二个是肌肉快速、程序性溶解的结果。这两种类型似乎都是由内分泌因素介导的。缓慢的萎缩是由类固醇蜕皮激素20-羟基蜕皮酮的下降引起的，可以用外源性类固醇来预防。快速变性是由肽羽化激素触发的，但肌肉对肽的敏感性取决于肌肉接触 20-羟基蜕皮激素的历史。
Two types of cell death occur in the intersegmental muscles of the giant silkmothAntheraea polyphemus. The first results from a slow atrophy of the fibers, and the second is a rapid, programmed dissolution of the muscle. Both types appear to be mediated by endocrine factors. The slow atrophy is brought about by the decline in the steroid molting hormone 20-hydroxyecdysone and can be prevented with exogenous steroid. The rapid degeneration is triggered by the peptide eclosion hormone, but the sensitivity of the muscle to the peptide depends on the history of exposure of the muscle to 20-hydroxyecdysone.