Pathogenesis of respiratory syncytial virus infection.
Pathogenesis of respiratory syncytial virus infection.
复制标题
DOI：
10.1089/0882824041310513
复制
发表时间：
2004-07
期刊：
影响因子：
2.2
通讯作者：
R. Tripp
中科院分区：
文献类型：
--
作者：
R. Tripp
呼吸道合胞病毒（RSV）被认为是全世界婴幼儿严重下呼吸道疾病的最重要病因，可导致终生重复感染，并在老年人和免疫功能低下患者中发生严重并发症。与RSV感染相关的疾病发病机制水平在病毒消除和对感染的免疫反应之间是平衡的。对RSV感染的先天和适应性免疫反应尚未完全阐明；然而，在了解病毒-宿主关系和与疾病发病机制相关的机制方面取得了重大进展。这篇综述总结了这些发现的重要方面，并提供了可能有助于RSV疾病发病机制的过程的当前观点。
Respiratory syncytial virus (RSV) is recognized as the most important cause of serious lower respiratory tract illness in infants and young children worldwide causing repeat infections throughout life with serious complications occurring in the elderly and immune compromised patient. The level of disease pathogenesis associated with RSV infection is balanced between virus elimination and the nature of the immune response to infection. The innate and adaptive immune responses to RSV infection are not fully elucidated; however, significant progress has been made in understanding the virus-host relationship and mechanisms associated with disease pathogenesis. This review summarizes important aspects of these findings, and provides current perspective on processes that may contribute to RSV disease pathogenesis.