Effects of perinatal exposure to bisphenol A on the behavior of offspring in F344 rats
Effects of perinatal exposure to bisphenol A on the behavior of offspring in F344 rats
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DOI：
10.1016/s1382-6689(03)00044-9
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发表时间：
2003-09-01
影响因子：
4.3
通讯作者：
Yoshikawa, Y
中科院分区：
文献类型：
--
作者：
Negishi, T;Kawasaki, K;Yoshikawa, Y
本研究的目的是评估围产期母亲每天接触双酚 A (BPA) 4、40 和 400 mg/kg 是否会影响 F344 大鼠后代的行为。围产期 BPA 暴露以剂量依赖性方式抑制雄性和雌性后代的体重增加，这种情况在断奶后持续存在。自发活动分析表明，BPA 延长了雌性后代在黑暗阶段的不动时间。 4 周龄时，每天接触 40 和 400 mg/ka BPA 的雄性后代在穿梭箱回避测试中表现出明显更高的回避反应。然而，在 8 周龄时，每天仅服用 4 毫克/公斤的雄性后代表现出明显较低的反应。在 8 周龄的旷场行为测试中，每天仅接触 4 毫克/公斤 BPA 的雄性后代表现出比对照雄性后代更高的梳理行为百分比。总之，围产期接触 BPA 会导致后代的行为改变。 (C) 2003 Elsevier B.V. 保留所有权利。
The objective of this investigation is to evaluate whether perinatal maternal exposure to bisphenol A (BPA) at 4, 40, and 400 mg/kg per day affects the behavior of offspring in F344 rats. Perinatal BPA exposure inhibited the body weight increases of male and female offspring in a dose-dependent manner, which continued after weaning. Spontaneous activity analyses revealed that BPA elongated immobile time during the dark phase in female offspring. At 4 weeks of age, male offspring exposed to BPA at 40 and 400 mg/ka per day performed avoidance responses significantly higher in the shuttlebox avoidance test. At 8 weeks of age, however, male offspring only at 4 mg/kg per day showed significantly lower responses. In the open-field behavior test at 8 weeks of age, male offspring exposed to BPA only at 4 mg/kg per day showed a higher percent of grooming than the control male offspring. In conclusion, perinatal exposure to BPA caused the behavioral alterations in the offspring. (C) 2003 Elsevier B.V. All rights reserved.