The relationship between congenital malformations and preterm birth
The relationship between congenital malformations and preterm birth
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DOI：
10.1515/jpm.2007.132
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Visintainer, Paul
中科院分区：
文献类型：
--
作者：
Kase, Jordan S.;Visintainer, Paul
目的：为了探讨如何先天性畸形（CM）与早产（PT）births.Methods：人口队列研究分析数据从纽约州先天性畸形登记处看活产从下哈德逊河谷地区从2000年至2003年。ICD 9代码识别了除多发畸形病例外的所有CM病例和类型。受试者被分为三个胎龄（GA）组之一。仅纳入出生时已知GA的病例。Poisson回归分析建立了早产CM的风险比。结果：PT出生率为11.2%，CM率为3%。与足月儿相比，CM患儿出生时更有可能发生PT（RR：2.20; CI：2.01-2.40）、中度早产（FIR：1.95; CI：1.76-2.15）和极早产（RR：3.45; CI：2.95-4.04）。当单独检查时，评价的大多数器官系统和畸形类型均保持这种关系。结论：先天性畸形对早产的发生有显著影响，并与早产的程度有关。
Aims: To investigate how congenital malformations (CM) are associated with preterm (PT) births.Methods: A population cohort study analyzed data from the New York State Congenital Malformations Registry to look at live births from the Lower Hudson Valley Region from 2000-2003. ICD9 codes identified all cases and types of CM in addition to cases with multiple malformations. Subjects were categorized into one of three gestational age (GA) groups. Only cases with a known GA at birth were included. Poisson regression analysis established a risk ratio for children born with a CM of being born preterm.Results: The PT birth rate was 11.2% and the CM rate 3%. Children with a CM were more likely to be born PT (RR: 2.20; Cl: 2.01-2.40), moderately preterm (FIR: 1.95; Cl: 1.76-2.15), and very preterm (RR: 3.45; Cl: 2.95-4.04) than term. This relationship was maintained for most organ systems and malformation types evaluated when checked individually. Being born with more than one CM increased the likelihood of being born PT (OR: 1.72; Cl: 1.37-2.15).Conclusions: Congenital malformations in children have a significant impact upon the likelihood of being born PT, and contribute significantly to the degree of prematurity.