Toxicity and bioaccumulation of xenobiotic organic compounds in the presence of aqueous suspensions of aggregates of nano-C60
Toxicity and bioaccumulation of xenobiotic organic compounds in the presence of aqueous suspensions of aggregates of nano-C60
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DOI：
10.1016/j.aquatox.2007.11.019
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发表时间：
2008-02-18
影响因子：
4.5
通讯作者：
Koch, C. B.
中科院分区：
文献类型：
--
作者：
Baun, A.;Sorensen, S. N.;Koch, C. B.
在一系列藻类（Pseudokirchneriella subcapilata）和甲壳动物（Daphnia magna）毒性试验中，研究了C-60纳米颗粒（巴克纳米富勒烯）作为水系统中污染物载体的潜力。以阿特拉津、甲基对硫磷、五氯酚和菲4种常见的环境污染物为模型化合物，研究了它们的理化性质和毒性作用方式。在测试前5天，将在水中搅拌2个月形成的纳米C-60聚集体与模型化合物混合。4日龄D.在水悬浮液中加入和不加入C-60的情况下研究magna。结果表明，85%的菲吸附在大于200 nm的C-60-聚集体上，而阿特拉津、甲基对硫磷和五氯苯酚的吸附率仅为10%。在藻类试验中，C-60-聚集体的存在使菲的毒性增加了60%，使五氯苯酚的毒性降低了约1.9倍。C_（60）团聚体的加入使五氯苯酚的毒性降低了25%。magna，而当结果以水相浓度表示时，观察到菲的毒性增加了10倍以上。因此，从两个毒性试验的结果表明，菲吸附到C60-聚集体是可用于生物体。对于阿特拉津和甲基敌百虫，由于C-60聚集体的存在，在藻类和水蚤试验中未观察到毒性的统计学显著差异。菲在D. magna发现，当C60存在于悬浮液中时，菲的吸收更快，并且在动物中达到1.7倍的稳态浓度。然而，当动物被转移到干净的水中时，发生了非常快的清除，导致菲没有积累。本研究首次证明了C60聚集体对其他环境相关污染物的水生毒性和生物累积性的影响。所提供的数据强调，不仅人造纳米颗粒的固有毒性，而且与其他化合物的相互作用和纳米颗粒在水悬浮液中的表征对于纳米材料的风险评估也很重要。(c)2007 Elsevier B. V.保留所有权利。
The potential Of C-60-nanoparticles (Buckminster fullerenes) as contaminant carriers in aqueous systems was studied in a series of toxicity tests with algae (Pseudokirchneriella subcapilata) and crustaceans (Daphnia magna). Four common environmental contaminants (atrazine, methyl parathion, pentachlorophenol (PCP), and phenanthrene) were used as model Compounds, representing different physico-chemical properties and toxic modes of action. The aggregates of nano-C-60 formed over 2 months of stirring in water were mixed with model compounds 5 days prior to testing. Uptake and excretion of phenanthrene in 4-days-old D. magna was studied with and without addition Of C-60 in aqueous suspensions. It was found that 85% of the added phenanthrene sorbed to C-60-aggregates >200 nm whereas about 10% sorption was found for atrazine, methyl parathion, and pentachlorophenol. In algal tests, the presence of C-60-aggregates increased the toxicity of phenanthrene with 60% and decreased toxicity of PCP about 1.9 times. Addition Of C60-aggregates reduced the toxicity of PCP with 25% in tests with D. magna, whereas a more than 10 times increase in toxicity was observed for phenanthrene when results were expressed as water phase concentrations. Thus, results from both toxicity tests show that phenanthrene sorbed to C60-aggregates is available for the organisms. For atrazine and methyl parathion no statistically significant differences in toxicities could be observed in algal and daphnid tests as a result of the presence of C-60-aggregates. In bioaccumulation studies with phenanthrene in D. magna it was found that the uptake of phenanthrene was faster when C60 was present in suspension and that a 1.7 times higher steady-state concentration was reached in the animals. However, a very fast clearance took place when animats were transferred to clean water resulting in no accumulation of phenanthrene. This study is the first to demonstrate the influence Of C60-aggregates on aquatic toxicity and bioaccumulation of other environmentally relevant contaminants. The data provided underline that not only the inherent toxicity of manufactured nanoparticles, but also interactions with other compounds and characterisation of nanoparticles in aqueous suspension are of importance for risk assessment of nanomaterials. (c) 2007 Elsevier B.V. All rights reserved.