The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects.
The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects.
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DOI：
10.1097/scs.0000000000003893
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
Chan CKF
中科院分区：
文献类型：
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作者：
Murphy MP;Irizarry D;Lopez M;Moore AL;Ransom RC;Longaker MT;Wan DC;Chan CKF
颅面外科自成立以来，一直是解决复杂的先天性，发育不良，肿瘤和创伤性颅骨缺损的合作努力的高潮。现在，距离第一次颅面会议已有50年，外科医生，科学家和生物工程师之间的合作努力正在进一步推进颅面手术，并在组织再生方面有了新的发现。再生医学和干细胞生物学的最新进展已经改变了作者对骨愈合的理解，干细胞在骨愈合中的作用，以及生态位环境和细胞外基质对干细胞命运的影响。本文旨在总结这些领域的进展。
Craniofacial surgery, since its inauguration, has been the culmination of collaborative efforts to solve complex congenital, dysplastic, oncological, and traumatic cranial bone defects. Now, 50 years on from the first craniofacial meeting, the collaborative efforts between surgeons, scientists, and bioengineers are further advancing craniofacial surgery with new discoveries in tissue regeneration. Recent advances in regenerative medicine and stem cell biology have transformed the authors’ understanding of bone healing, the role of stem cells governing bone healing, and the effects of the niche environment and extracellular matrix on stem cell fate. This review aims at summarizing the advances within each of these fields.