A SUGGESTED APPROACH TO ONCE-DAILY AMINOGLYCOSIDE DOSING
A SUGGESTED APPROACH TO ONCE-DAILY AMINOGLYCOSIDE DOSING
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DOI：
10.1111/j.1365-2125.1995.tb05719.x
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发表时间：
1995-06-01
影响因子：
3.4
通讯作者：
DUFFULL, SB
中科院分区：
文献类型：
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作者：
BEGG, EJ;BARCLAY, ML;DUFFULL, SB
1每天服用一次氨基糖苷类药物有许多优点，并得到了广泛的倡导。然而，现有的给药和监测方法指南是非特异性的，可能会导致过量给药。2以目标浓度为目标峰和谷浓度的传统方法不适用于每天一次的给药。3提出了一种方法，该方法基于常规给药产生的24小时AUC，在氨基糖苷浓度-时间曲线(AUC)下使用靶区。该方法需要测量两种药物浓度，一种在输注结束后约0.5小时，另一种在随后的时间(6-22小时)，视肾功能而定。4对于肾功能正常的患者，还提出了一种更简单的图解方法，要求在6至14小时之间一次测量一种药物浓度。5这两种方法都可能比现有的指南更安全。
1 Once-daily aminoglycoside dosing has many advantages and has been widely advocated. However, existing guidelines for methods of administration and monitoring are non-specific and may lead to excessive dosing.2 The traditional approach of aiming for target peak and trough concentrations is not appropriate for once-daily dosing.3 A method is proposed which uses a target area under the concentration-time curve (AUC) for the aminoglycoside based on the 24 h AUC that would result with conventional dosing. This method requires measurement of two drug concentrations, one approximately 0.5 h after the end of the infusion and another at a later time (6-22 h) depending on renal function.4 A simpler, graphical method is also proposed for patients with normal renal function, which requires the measurement of a single concentration at a time between 6 and 14 h.5 Both methods are likely to be safer than existing guidelines.