Spatial and nonspatial learning across the rat estrous cycle.
Spatial and nonspatial learning across the rat estrous cycle.
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DOI：
10.1037/0735-7044.111.2.259
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发表时间：
1997-04
影响因子：
1.9
通讯作者：
Stacey G. Warren;J. Juraska
中科院分区：
文献类型：
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作者：
Stacey G. Warren;J. Juraska
最近的证据表明，在整个雌性大鼠的发情周期中，海马体的解剖和生理都有波动。在本研究中，我们通过在发情周期的不同阶段对雌性进行海马体或非海马体莫里斯水迷宫测试，研究了这些变化的行为含义。男性也接受了这些任务的测试。尽管在非海马提示任务上差异不大，但发情期的雌性表现明显优于发情期的雌性。雌性在空间任务上的最佳表现出现在发情期，而最低效的表现出现在发情前期。这些结果不支持海马体长期增强与空间学习正相关的传统观点。
Recent evidence has demonstrated that there are fluctuations in both the anatomy and physiology of the hippocampus across the estrous cycle of the female rat. In the present study we examined the behavioral implications of these changes by testing females on either a hippocampal or nonhippocampal version of the Morris water maze during the various phases of the estrous cycle. Males were also tested on these tasks. Although there was little variance on the nonhippocampal cue task, females in proestrus performed significantly better than those in estrus. Optimal female performance on the spatial version of the task occurred during the phase of estrus, whereas the least efficient performance occurred during proestrus. These results do not support the traditional view that hippocampal long-term potentiation is positively correlated with spatial learning.