Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjögren's syndrome.
Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjögren's syndrome.
复制标题
DOI：
10.1016/s0161-6420(90)32372-2
复制
发表时间：
1990-12
期刊：
影响因子：
13.7
通讯作者：
J. Pepose;R. F. Akata;S. Pflugfelder;W. Voigt
中科院分区：
文献类型：
--
作者：
J. Pepose;R. F. Akata;S. Pflugfelder;W. Voigt
对8例干燥综合征患者泪腺活检的免疫细胞化学研究显示，单个核细胞浸润物的主要成分是B细胞和Leu-3+T辅助细胞，它们的存在远远超过对照腺体。在七个接受测试的病例中，有三个含有抗EB病毒(EBV)不同成分的单抗染色的细胞；其中一个活检组织还含有携带巨细胞病毒抗原的细胞。免疫球蛋白基因重排，但没有T细胞受体重排，在Sjören的两个泪腺活检中的一个被证实。作者认为，干燥综合征患者泪腺组织小管腺泡结构的破坏似乎继发于B细胞和辅助性T细胞的淋巴增殖，它们可能来源于初级淋巴滤泡。在选择性病例中，泪腺组织感染EBV可能在该综合征的发病机制中起一定作用。
Immunocytochemical studies of lacrimal gland biopsies obtained from eight patients with Sjögren's syndrome revealed the major component of the mononuclear cell infiltrates to be comprised of B cells and Leu-3+T-helper cells, which were present well in excess of control glands. Three of seven cases that were tested harbored cells that stained with monoclonal antibodies against different components of Epstein-Barr virus (EBV); one of the biopsies also contained cells that bore cytomegalovirus antigens. Immunoglobulin-gene rearrangements, but not T-cell receptor rearrangements, were demonstrated in one of two Sjören's lacrimal gland biopsies tested. The authors conclude that the destruction of the tubuloacinar architecture of lacrimal gland tissue in Sjögren's syndrome appears secondary to lymphoproliferation of B cells and T-helper cells, probably derived from primary lymphoid follicles. Productive infection of lacrimal gland tissue with EBV may play a role in the pathogenesis of the syndrome in selective cases.