Prefrontal cortex hemodynamic activity during a test of lower extremity functional muscle strength in children with cerebral palsy: A functional near-infrared spectroscopy study.
Prefrontal cortex hemodynamic activity during a test of lower extremity functional muscle strength in children with cerebral palsy: A functional near-infrared spectroscopy study.
复制标题
脑瘫儿童下肢功能性肌力测试过程中前额皮质血流动力学活动：功能性近红外光谱研究。
DOI：
10.1111/ejn.16211
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Modlesky,ChristopherM
中科院分区：
文献类型：
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作者：
Licea,Joel;Khan,OwaisA;Singh,Tarkeshwar;Modlesky,ChristopherM
脑性瘫痪（CP）儿童表现出受损的运动控制和显着的肌肉无力，由于大脑病变。然而，研究，评估大脑活动和性能之间的关系，在CP的动态功能性肌肉力量评估是必要的。本研究的目的是确定进行性横向递增试验对CP儿童前额叶皮质（PFC）血流动力学活动的影响。14名患有痉挛性CP（粗大运动功能分类系统I级; 5-11岁）的非卧床儿童和14名年龄和性别匹配的发育正常的对照儿童使用其非优势下肢在增量台阶高度（0、10、15和20 cm）处完成了进行性侧向台阶测试。使用无创、便携式功能神经成像（功能性近红外光谱）评估PFC中的血流动力学活动。与对照组相比，CP儿童在每个台阶高度完成的重复次数较少，并且在整个台阶高度上表现出较低的PFC血流动力学活动。在统计学上控制在每个台阶高度完成的重复次数后，CP中的PFC激活较低。在CP儿童中，PFC血流动力学活动与LSUT任务表现无关，但在最具挑战性的20 cm台阶高度的对照组中观察到正相关关系。结果表明，在一个高度动态的功能强度测试过程中，CP儿童的PFC募集模式发生了改变。需要进一步的研究来探讨与正常发育儿童相比，CP儿童中观察到的PFC激活受抑制的机制。
Children with cerebral palsy (CP) exhibit impaired motor control and significant muscle weakness due to a brain lesion. However, studies that assess the relationship between brain activity and performance on dynamic functional muscle strength assessments in CP are needed. The aim of this study was to determine the effect of a progressive lateral step‐up test on prefrontal cortex (PFC) hemodynamic activity in children with CP. Fourteen ambulatory children with spastic CP (Gross Motor Function Classification System level I; 5–11 y) and 14 age‐ and sex‐matched typically developing control children completed a progressive lateral step‐up test at incremental step heights (0, 10, 15 and 20 cm) using their non‐dominant lower limb. Hemodynamic activity in the PFC was assessed using non‐invasive, portable functional neuroimaging (functional near‐infrared spectroscopy). Children with CP completed fewer repetitions at each step height and exhibited lower PFC hemodynamic activity across step heights compared to controls. Lower PFC activation in CP was maintained after statistically controlling for the number of repetitions completed at each step height. PFC hemodynamic activity was not associated with LSUT task performance in children with CP, but a positive relationship was observed in controls at the most challenging 20 cm step height. The results suggest there is an altered PFC recruitment pattern in children with CP during a highly dynamic test of functional strength. Further studies are needed to explore the mechanisms underlying the suppressed PFC activation observed in children with CP compared to typically developing children.