Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions.
Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions.
复制标题
精神分裂症患者海马亚区神经元尺寸较小，介导皮质-海马相互作用。
DOI：
10.1176/ajp.152.5.738
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Trojanowski,JQ
中科院分区：
文献类型：
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作者：
Arnold,SE;Franz,BR;Gur,RC;Gur,RE;Shapiro,RM;Moberg,PJ;Trojanowski,JQ
目的通过测量神经元密度、神经元大小和神经元轴向变异性，探讨精神分裂症患者海马结构的特征。方法在尸检时获得14例慢性精神分裂症老年患者和10例无精神障碍的年龄相容个体的脑组织。在nsil染色切片上鉴定出八个感兴趣的海马区域和两个内部控制区域（初级运动和视觉皮质）。形态测量是在不知道诊断的情况下通过计算机图像分析系统进行的。结果与对照组相比，患者海马区神经元体积较小，且仅耻骨下、CA1和内嗅皮层第二层神经元体积较小。两组控制区的神经元大小几乎相同。在神经元密度或神经轴方向的可变性中，没有发现任何区域的显著差异。除内嗅皮层第二层与年龄负相关外，任何区域的神经元大小与几个潜在的混淆变量（年龄、死后间隔、服用抗精神病药、性别、研究的大脑半球、疾病持续时间）均无相关性。回归分析表明，这些发现不能归因于这些年龄的影响。结论海马体的主要亚区是枕下、内嗅皮层和CA1，它们维持着海马体与广泛的皮层和皮层下靶点之间的传入和传出连接。这些子区中较小的神经元可能反映了破坏这些连接的结构或功能损伤的存在，这反过来可能会产生重要的行为后遗症。
ObjectiveThe goal of this study was to characterize the hippocampal formation in patients with schizophrenia by measuring neuron density, neuron size, and variability of neuronal axis orientation.MethodBrain tissue was obtained at autopsy from 14 prospectively accrued elderly patients with chronic schizophrenia and 10 age-compatible individuals without psychiatric disorder. Eight hippocampal regions of interest and two internal control regions (primary motor and visual cortices) were identified on Nissl-stained sections. Morphometric measurements were made without knowledge of diagnosis by means of a computer-based image analysis system.ResultsThe patients exhibited smaller neuron size in the hippocampal regions relative to the control regions, which was significant only for the subiculum, CA1, and layer II of the entorhinal cortex. Neuron size in the control regions was nearly identical in the two groups. No significant differences in neuron density or in variability of neuronal axis orientation were identified for any region. There was no correlation between neuron size in any area and several potentially confounding variables (age, post-mortem interval, neuroleptic exposure, sex, brain hemisphere studied, duration of illness), with the exception of a negative correlation with age in layer II of the entorhinal cortex. Regression analyses indicated that the findings could not be attributed to these age effects.ConclusionsThe subiculum, entorhinal cortex, and CA1 are the major subfields of the hippocampal region that maintain the afferent and efferent connections of the hippocampus with widespread cortical and subcortical targets. The smaller size of neurons in these subfields may reflect the presence of structural or functional impairments that disrupt these connections, which in turn could have important behavioral sequelae.