Stem cell biology in the lung and lung cancers: using pulmonary context and classic approaches.
Stem cell biology in the lung and lung cancers: using pulmonary context and classic approaches.
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肺癌和肺癌中的干细胞生物学：使用肺部背景和经典方法。
DOI：
10.1101/sqb.2008.73.036
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kim,CF
中科院分区：
文献类型：
--
作者：
Raiser,DM;Zacharek,SJ;Roach,RR;Curtis,SJ;Sinkevicius,KW;Gludish,DW;Kim,CF
需要专门针对肺生物学的经典干细胞生物学方法，以使肺干细胞生物学领域与其他组织同步。在干细胞研究中，必须考虑到该器官中不频繁的细胞更新、细胞类型的多样性以及日常细胞功能的必要性。以前的工作已经建立了一个基础，从中探索移植，标签保留，和更复杂的谱系追踪计划，以确定和表征正常肺中的干细胞群。这些方法对于在探索肺癌中的癌症干细胞假说时建立在其他组织中的先例也是必要的。此外，最近的研究提供了关键线索，以进一步探索调节肺稳态的分子机制。在这里，我们讨论了推进肺干细胞生物学领域的策略，重点是开发新的肺特异性工具。
Classic stem cell biology approaches tailored specifically with lung biology in mind are needed to bring the field of lung stem cell biology up to speed with that in other tissues. The infrequent cellular turnover, the diversity of cell types, and the necessity of daily cell function in this organ must be considered in stem cell studies. Previous work has created a base from which to explore transplantation, label retention, and more sophisticated lineage-tracing schemes to identify and characterize stem cell populations in the normal lung. These approaches are also imperative for building on precedents set in other tissues in the exploration of the cancer stem cell hypothesis in lung cancers. Additionally, recent studies provide key leads to further explore the molecular mechanisms that regulate lung homeostasis. Here, we discuss strategies to advance the field of lung stem cell biology with an emphasis on developing new, lung-specific tools.