The NIH MRI study of normal brain development (Objective-2): Newborns, infants, toddlers, and preschoolers
The NIH MRI study of normal brain development (Objective-2): Newborns, infants, toddlers, and preschoolers
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DOI：
10.1016/j.neuroimage.2006.08.058
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发表时间：
2007-03-01
期刊：
影响因子：
5.7
通讯作者：
McKinstry, R. C.
中科院分区：
文献类型：
--
作者：
Almli, C. R.;Rivkin, M. J.;McKinstry, R. C.
马格。共振。大脑发育合作小组目前对正常大脑发育进行的成像 (MRI) 研究是迄今为止对从出生到成年早期的大脑和行为发育进行的最广泛的 MRI 研究。这个多中心项目由美国国立卫生研究院四个研究所赞助，采用纵向和横向相结合的设计来表征正常、健康的大脑和行为发育。新生儿至 18 岁以上的儿童通过 Objective-2（出生至 4 岁 5 个月）和 Objective-1（4 岁 6 个月至 18 岁及以上）接受全面的行为、神经学和多模式 MRI 评估。本报告介绍了从新生儿到 4 岁 5 个月大的儿童的方法（例如神经行为评估、脑部扫描）和代表性初步结果（例如生长、行为、大脑发育）。迄今为止，已经成功对 75 名从出生到 4 岁 5 个月的参与者在自然睡眠（即不使用镇静剂）下进行了脑部扫描；大多数儿童进行多次纵向扫描（即 45 名儿童完成至少 3 次扫描，22 名儿童完成 4 次或更多扫描）。这个年轻年龄范围的结果将增加我们对人类生命周期中重要、动态和快速生长期的健康大脑和神经行为发育的认识和理解；确定大脑测量、其他身体特征和行为之间的发育关联；促进新生儿、婴儿和幼儿自动化定量 MR 图像分析的开发。相关的脑部 MRI 和神经行为数据库将在未来发布，供研究和临床界使用。 (c) 2006 Elsevier Inc. 保留所有权利。
The Magn. Reson. Imaging (MRI) study of normal brain development currently conducted by the Brain Development Cooperative Group represents the most extensive MRI study of brain and behavioral development from birth through young adulthood ever conducted. This multi-center project, sponsored by four Institutes of the National Institutes of Health, uses a combined longitudinal and cross-sectional design to characterize normal, healthy brain and behavioral development. Children, ages newborn through 18-plus years of age, receive comprehensive behavioral, neurological and multimodal MRI evaluations via Objective-2 (birth through 4-years 5-months of age) and Objective-1 (4-years 6-months through 18 years of age and older). This report presents methods (e.g., neurobehavioral assessment, brain scan) and representative preliminary results (e.g., growth, behavior, brain development) for children from newborn through 4-years 5-months of age. To date, 75 participants from birth through 4-years 5-months have been successfully brain scanned during natural sleep (i.e., without sedation); most with multiple longitudinal scans (i.e., 45 children completing at least three scans, 22 completing four or more scans). Results from this younger age range will increase our knowledge and understanding of healthy brain and neurobehavioral development throughout an important, dynamic, and rapid growth period within the human life span; determine developmental associations among measures of brain, other physical characteristics, and behavior; and facilitate the development of automated, quantitative MR image analyses for neonates, infants and young children. The correlated brain MRI and neurobehavioral database will be released for use by the research and clinical communities at a future date. (c) 2006 Elsevier Inc. All rights reserved.