Bolus delay and dispersion in perfusion MRI: Implications for tissue predictor models in stroke
Bolus delay and dispersion in perfusion MRI: Implications for tissue predictor models in stroke
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DOI：
10.1002/mrm.20873
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发表时间：
2006-05-01
影响因子：
3.3
通讯作者：
Connelly, A
中科院分区：
文献类型：
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作者：
Calamante, F;Willats, L;Connelly, A
通过动脉输入函数（AIF）的去卷积从动态磁敏感对比（DSC）-MRI数据计算的灌注图通常用于预测急性卒中中的组织梗死。然而，由于AIF通常在主动脉中测量，因此可能存在与推注延迟/分散相关联的灌注测量误差。虽然已经提出了解决延迟相关误差的方法，但色散的影响更难处理，通常不加校正。本研究评估了一组患者的延迟-弥散关系。虽然观察到与所用的一个推注延迟定义的显著相关性，但从延迟程度估计的分散度是不可靠的。重要的是，在许多患者中观察到的分散足以导致实质性灌注错误。结果与以前的数值模拟进行了比较，并讨论了其对急性中风的评估和管理的影响。
Perfusion maps, which are calculated from dynamic-susceptibility contrast (DSC)-MRI data by deconvolution of the arterial input function (AIF), are commonly used to predict tissue infarction in acute stroke. However, since the AIF is commonly measured in a major artery, there can be perfusion measurement errors associated with bolus delay/dispersion. Although methods to account for delay-related errors have been proposed, the effect of dispersion is more difficult to deal with and is usually left uncorrected. This study presents an assessment of the delay-dispersion relationship in a group of patients. Although a significant correlation was observed with one of the bolus delay definitions used, the estimation of the dispersion from the degree of delay was unreliable. Importantly, the dispersion observed in many patients was sufficient to result in substantial perfusion errors. The results are compared with previous numerical simulations, and their implications for the assessment and management of acute stroke are discussed.