Antinociception induced in rats by intrathecal administration of antiserum against calcitonin gene-related peptide
Antinociception induced in rats by intrathecal administration of antiserum against calcitonin gene-related peptide
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DOI：
10.1016/0304-3940(88)90611-8
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发表时间：
1988-10
影响因子：
2.5
通讯作者：
Y. Kuraishi;T. Nanayama;H. Ohno;M. Minami;M. Satoh
中科院分区：
文献类型：
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作者：
Y. Kuraishi;T. Nanayama;H. Ohno;M. Minami;M. Satoh
为了确定内源性降钙素基因相关肽（CGRP）是否参与脊髓背角的疼痛传递，在非关节炎和佐剂关节炎大鼠中检查了鞘内注射抗 CGRP 抗血清对爪压力测试中伤害性阈值的影响。鞘内注射抗血清可增加非关节炎动物的伤害性阈值，而 0.9% 盐水、免疫前血清和先前被合成 CGRP 吸收的抗血清则没有效果。佐剂关节炎大鼠表现出痛觉过敏，鞘内注射抗血清后情况有所改善。盐水和吸收的抗血清对痛觉过敏没有影响。这些结果表明，初级传入神经中存在的内源性 CGRP 可能对脊髓背角的伤害性传递具有促进作用。
To determine whether or not endogenous calcitonin gene-related peptide (CGRP) participates in pain transmission in the spinal dorsal horn, effects of an intrathecal injection of anti-CGRP antiserum on nociceptive threshold in the paw-pressure test was examined in non-arthritic and adjuvant arthritic rats. An intrathecal injection of the antiserum increased the nociceptive threshold in non-arthritic animals, while 0.9% saline, pre-immune serum and antiserum, previously absorbed by synthetic CGRP, were without effect. Adjuvant arthritic rats showed a hyperalgesia, and improvement occurred with intrathecal injection of the antiserum. Saline and absorbed antiserum were without effect on the hyperalgesia. These results suggest that the endogenous CGRP present in primary afferents probably has a facilitating function in nociceptive transmission in the spinal dorsal horn.