Low lumbar CSF levels of homovanillic acid and 5-hydroxyindoleacetic acid in multiple system atrophy with autonomic failure.
Low lumbar CSF levels of homovanillic acid and 5-hydroxyindoleacetic acid in multiple system atrophy with autonomic failure.
复制标题
多系统萎缩伴自主神经衰竭时腰椎脑脊液中高香草酸和 5-羟基吲哚乙酸水平低。
DOI：
10.1136/jnnp.51.7.914
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
I J Kopin
中科院分区：
文献类型：
--
作者：
R. Polinsky;Robert T. Brown;R. Burns;J. Harvey‐White;I J Kopin
伴有自主神经功能衰竭（MSA）的多系统萎缩患者的腰椎CSF中高香草酸（HVA）和5-羟基吲哚乙酸（5-HIAA）浓度较低，反映了中枢多巴胺能和多巴胺能通路的活性降低。这些神经化学变化与MSA的神经病理学受累一致，并将这些患者与CSF代谢物水平正常的纯自主神经功能衰竭患者区分开来。
Low lumbar CSF concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in patients with multiple system atrophy attended by autonomic failure (MSA) reflect decreased activity in central dopaminergic and serotonergic pathways. These neurochemical changes are consistent with the neuropathological involvement in MSA and distinguish such patients from those with pure autonomic failure who have normal CSF metabolite levels.