Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock?
Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock?
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DOI：
10.1016/j.psyneuen.2018.03.012
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发表时间：
2018-05-01
影响因子：
3.7
通讯作者：
Sharma, Anuradha
中科院分区：
文献类型：
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作者：
Gruetzner, Thea Marianne;Listunova, Lena;Sharma, Anuradha
背景：重性抑郁障碍（MDD）与认知功能障碍有关，认知功能障碍可能与钙稳态紊乱有关。钙相关过程也与年龄相关的认知能力下降有关。由于血清钙和脑间质液在正常生理状态下保持长期平衡，血清钙水平可影响神经元，从而影响认知功能。高血清钙与老年人群的认知能力下降有关，而MDD和健康人群的证据不太一致。方法：神经心理学（NP-R）表现的差异及其与血清钙的关系（总离子化、总离子化比）对在年龄、性别和教育程度（年龄范围19-60岁）方面单独匹配的（部分）缓解的MDD患者（n = 59）和健康对照（HC）（n = 59）进行了检查。研究了研究参数的调节及其与年龄因素的相互作用，年轻和老年亚组的中位数为37岁。参与者提供的血液样本，并完成了广泛的血液透析测试battery.Results：MDD表现出显着较差的血液透析性能相比，HC。在整个年龄范围的样本中，血清钙与HC的抗抑郁性能呈正相关，与MDD呈负相关。年轻的MDD和HC表现出正的NPS-钙相关性，而老年MDD和HC表现出负的NPS-钙相关性（“相关性反转”）。年龄有显着的影响，认知和离子钙和疾病状态的相互作用，夸大的影响，认知MDD相比HC.Conclusions：结果将钙的“相关逆转”到中年早期的时间窗口，这可能会加速MDD和突出钙通路在正常和病理性认知老化的核心作用。
Background: Major depressive disorder (MDD) is associated with cognitive impairment, that might be related to disturbed calcium homeostasis. Calcium-related processes have also been implicated in age related cognitive decline. Since serum calcium and brain interstitial fluids maintain long-term equilibrium under normal physiological states, serum calcium levels could affect neuronal and hence cognitive function. High serum calcium has been associated with cognitive decline in geriatric populations, whereas evidence for MDD and healthy populations is less consistent.Methods: Differences in neuropsychological (NPS) performance and their relationship with serum calcium (total, ionized, total to ionized ratio) in (partially) remitted MDD patients (n = 59) and healthy controls (HC) (n = 59) individually matched for age, gender and education (age-range 19-60 years) were examined. Modulation of study parameters and their interaction by the factor age was investigated, with subgroups young and old divided at median = 37 years. Participants provided blood samples and completed an extensive NPS test battery.Results: MDD showed significantly poorer NPS performance compared to HC. Serum calcium associated positively with NPS performance in HC and negatively in MDD for entire age-range samples. While younger MDD and HC showed positive NPS-calcium correlations, older MDD and HC exhibited negative NPS-calcium correlations ('correlation reversal'). Age had a significant effect on cognition and ionized calcium and interacted with illness-status, with an exaggerated influence on cognition in MDD compared to HC.Conclusions: The results place calcium 'correlation reversal' to early middle-age time window, which may be accelerated for MDD and highlight the central role of calcium pathways in normal and pathological cognitive aging.