Functional properties of striatal fast-spiking interneurons.
Functional properties of striatal fast-spiking interneurons.
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DOI：
10.3389/fnsys.2011.00045
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发表时间：
2011
影响因子：
3
通讯作者：
Berke JD
中科院分区：
文献类型：
--
作者：
Berke JD
纹状体快速尖峰中间神经元（FSI）对行为输出有重要影响，在肌张力障碍和抽动秽语综合征中观察到这些细胞的缺陷。FSI接受皮层输入，通过缝隙连接耦合在一起，并在许多附近的投射神经元上形成体周GABA能突触。尽管是纹状体微回路的关键组成部分，但直到最近，人们对行为动物的FSI活动知之甚少。纹状体FSI在清醒的啮齿动物中几乎是持续活跃的，但即使是相邻的FSI在大多数时间也表现出不相关的活动。当大鼠发起一个选择的动作同时抑制一个训练有素的替代动作时，整个纹状体就会出现FSI放电增加的协调“脉冲”。这种脉冲与苍白球人口活动的下降相吻合，表明苍白球纹状体去抑制可能在时间或协调行动执行中发挥重要作用。除了放电频率的变化，FSI显示出与行为相关的尖峰时间调制。在指令提示下，峰电位间期的变异性显著降低，FSI也参与了与奖励事件和多巴胺能药物有关的快速纹状体振荡。这些研究揭示了FSI的新的和意想不到的特性，这将有助于为正常和异常条件下纹状体信息处理的新模型提供信息。
Striatal fast-spiking interneurons (FSIs) have a major influence over behavioral output, and a deficit in these cells has been observed in dystonia and Tourette syndrome. FSIs receive cortical input, are coupled together by gap junctions, and make perisomatic GABAergic synapses onto many nearby projection neurons. Despite being critical components of striatal microcircuits, until recently little was known about FSI activity in behaving animals. Striatal FSIs are near-continuously active in awake rodents, but even neighboring FSIs show uncorrelated activity most of the time. A coordinated “pulse” of increased FSI firing occurs throughout striatum when rats initiate one chosen action while suppressing a highly trained alternative. This pulse coincides with a drop in globus pallidus population activity, suggesting that pallidostriatal disinhibition may have a important role in timing or coordinating action execution. In addition to changes in firing rate, FSIs show behavior-linked modulation of spike timing. The variability of inter-spike intervals decreases markedly following instruction cues, and FSIs also participate in fast striatal oscillations that are linked to rewarding events and dopaminergic drugs. These studies have revealed novel and unexpected properties of FSIs, that should help inform new models of striatal information processing in both normal and aberrant conditions.