Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations
Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations
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DOI：
10.1016/j.psyneuen.2014.10.001
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发表时间：
2015-01-01
影响因子：
3.7
通讯作者：
Dannlowski, Udo
中科院分区：
文献类型：
--
作者：
Opel, Nils;Redlich, Ronny;Dannlowski, Udo
肥胖是重度抑郁症（MDD）最常见的躯体合并症之一。这两种疾病都是公共卫生面临的主要挑战之一，并以部分重叠的大脑结构中的灰质改变为独立特征。因此，研究这种常见合并症的共同神经结构相关性及其临床意义的可能性似乎至关重要。144名急性重度抑郁症患者和141名健康对照者进行了结构MRI检查。使用基于体素的形态测量（VBM）对成像数据进行分析。评估身体质量指数（BMI）以及疾病状态和病程。在MOD患者和健康对照组中，较高的BMI与内侧前额叶皮层、眶额叶皮层、尾状核和丘脑灰质减少的模式高度相似。在mdd患者中，BMI与更慢性的病程相关，BMI和疾病的慢性性都与内侧前额叶区相似的形态测量异常有关。在重度抑郁症中，肥胖受试者的特点可能是病程较慢。此外，肥胖和慢性疾病似乎在涉及情绪调节和冲动控制的前额叶区域共享重叠的神经结构异常。因此，我们的数据为这种普遍的合并症背后的特定形态改变提供了证据。它进一步强调了预防肥胖伴随重度抑郁症治疗的临床重要性。(C) 2014 Elsevier Ltd.版权所有。
Obesity is one of the most prevalent somatic comorbidities of major depressive disorder (MDD). Both disorders rank among the leading challenges in public health and have been independently characterized by gray matter alterations in partly overlapping brain structures. Hence, it appears crucial to investigate the possibility of a shared neurostructural correlate of this frequent comorbidity as well as its clinical implications.One hundred and fourty-four patients suffering from acute MDD and 141 healthy control subjects underwent structural MRI. Imaging data were analyzed using voxel-based morphometry (VBM). Body-mass-index (BMI) as well as state and course of disease were assessed.Higher BMI was associated with a highly comparable pattern of gray matter reductions in the medial prefrontal cortex, the orbitofrontal cortex, the caudate nucleus and the thalamus in MOD patients and healthy controls alike. In MDD-patients, BMI was associated with a more chronic course of disease and both BMI and chronicity of disorder were related to similar morphometric anomalies in medial prefrontal areas.In MDD, obese subjects might be characterized by a more chronic course of disease. Moreover, obesity and chronicity of disorder seem to share overlapping neurostructural anomalies in prefrontal areas involved in emotion regulation and impulse control. Hence, our data provide evidence for specific morphological alterations underlying this prevalent comorbidity. It further underlines the clinical importance of preventive measures against obesity accompanying MDD treatment. (C) 2014 Elsevier Ltd. All rights reserved.