A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population
A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population
复制标题
microRNA196a基因组区域的多态性与中国人群患神经胶质瘤的风险降低相关
DOI：
10.1007/s00432-010-0844-5
复制
发表时间：
2010-12-01
影响因子：
3.6
通讯作者：
Lu, Daru
中科院分区：
文献类型：
--
作者：
Dou, Tonghai;Wu, Qihan;Lu, Daru
MicroRNA (miRNA) 是小型非编码 RNA，在真核基因表达调控中发挥重要作用。 miRNA 的异常表达和结构改变被认为参与肿瘤发生和癌症发展。最近，发现不同基因型的miR-196a多态性（SNP，rs11614913）与肺癌患者的生存和乳腺癌风险增加相关。为了进一步研究这种多态性是否会影响神经胶质瘤的风险，我们检查了中国人群中的 SNP 等位基因频率。我们的数据显示，miR-196a（rs11614913）基因型CC多态性与中国人群患神经胶质瘤的风险降低相关（OR = 0.74，95% CI：0.56–0.98）。此外，在成人神经胶质瘤（OR = 0.73，95% CI：0.55–0.98）、男性神经胶质瘤（OR = 0.69，95% CI：0.48–0.99）和胶质母细胞瘤患者（OR = 0.58，95%）亚组中，观察到该基因型与神经胶质瘤风险之间存在显着相关性。置信区间：0.37–0.91）。这是第一项调查 miR-196ars11614913 与神经胶质瘤风险之间关联的研究。与之前肺癌和乳腺癌研究的结果相比，我们的数据表明神经胶质瘤中存在不同的基因型关联。这可能与组织起源、肿瘤类型、肿瘤发生、发展过程的多样性有关。
MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in regulation of eukaryotic gene expression. Aberrant expression and structural alternation of miRNAs are considered to participate in tumorigenesis and cancer development. Recently, different genotypes ofmiR-196apolymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer. To further investigate whether this polymorphism may influence glioma risk or not, we examined the SNP allele frequency in Chinese population. Our data shows the genotype CC ofmiR-196a(rs11614913) polymorphism is associated with decreased risk of glioma in the Chinese population (OR = 0.74, 95% CI:0.56–0.98). Furthermore, a significant association was observed between this genotype and glioma risk in the subgroups of adult glioma (OR = 0.73, 95% CI:0.55–0.98), male glioma (OR = 0.69, 95% CI:0.48–0.99) and patients with glioblastoma (OR = 0.58, 95% CI:0.37–0.91). This was the first study investigating the association between themiR-196ars11614913 and glioma risk. Compared with the results from previous studies in lung cancer and breast cancer, our data suggest a different genotype association in glioma. This may be related to the diversity on the tissue origin, tumor type, tumorigenesis, and developing process.