PLASMA-HORMONE LEVELS IN WOMEN RECEIVING NEW ORAL-CONTRACEPTIVES CONTAINING ETHINYL ESTRADIOL PLUS LEVONORGESTREL OR DESOGESTREL
PLASMA-HORMONE LEVELS IN WOMEN RECEIVING NEW ORAL-CONTRACEPTIVES CONTAINING ETHINYL ESTRADIOL PLUS LEVONORGESTREL OR DESOGESTREL
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DOI：
10.1016/0010-7824(83)90023-9
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发表时间：
1983-01-01
期刊：
影响因子：
2.9
通讯作者：
FRANCHIMONT, P
中科院分区：
文献类型：
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作者：
GASPARD, UJ;ROMUS, MA;FRANCHIMONT, P
在匹配的健康女性志愿者中，在6个月前和后观察血浆激素水平的变化。使用3种新的口服避孕药（OC）：Trigynon（n = 13），一种含有低剂量乙炔基炔雌醇（EE）+左炔诺孕酮（LNg）的三相OC; Marvelon（n = 14），一种含有低剂量EE +去氧孕烯（DOG，一种衍生自LNg的新孕激素）的单相OC;和Ovidol（n = 10），一种含有较高剂量（50 μ g）EE + DOG的序贯OC。所有病例的血清FSH、LH [促黄体生成素]、雌二醇和孕酮水平均降低至与排卵不相容的水平。催乳素浓度不变。所有3种OC（Ovidol > Marvelon > Trigynon）均显著增加性激素结合球蛋白（SHBG）和转皮质素（CBG）水平;游离睾酮水平显著降低，而游离皮质醇浓度保持不变。所有3种OC都是有效的排卵抑制剂，Ovidol和Marvelon比Trigynon具有更大的雌激素效应，LNg在减少EE诱导的SHBG水平升高方面比DOG更有效，并且所有3种OC都同样有效地抑制游离睾酮水平。
The changes in plasma hormone levels were evaluated in matched healthy female volunteers investigated before and after 6 mo. use of 3 new oral contraceptives (OC): Trigynon (n = 13), a triphasic OC containing low doses of ethynylestradiol (EE) + levonorgestrel (LNg); Marvelon (n = 14), a monophasic OC containing low doses of EE + desogestrel (DOG, a new progestogen derived from LNg); and Ovidol (n = 10), a sequential OC containing higher doses (50 .mu.g) of EE + DOG. Serum levels of FSH, LH [luteinizing hormone], estradiol and progesterone were decreased in all cases to levels incompatible with ovulation. Prolactin concentrations were unchanged. Sex hormone binding globulin (SHBG) and transcortin (CBG) levels were significantly increased by all 3 OC (Ovidol > Marvelon > Trigynon); free testosterone levels decreased significantly while free cortisol concentrations remained unchanged. All 3 OC are effective ovulation inhibitors, Ovidol and Marvelon have greater estrogenic effects than Trigynon, LNg is more effective than DOG in reducing the EE-induced increase in SHBG levels, and free testosterone levels are equally well suppressed by all 3 OC.