PLASMA ASCORBATE CONCENTRATIONS AND BLOOD-CELL DEHYDROASCORBATE TRANSPORT IN PATIENTS WITH DIABETES-MELLITUS
PLASMA ASCORBATE CONCENTRATIONS AND BLOOD-CELL DEHYDROASCORBATE TRANSPORT IN PATIENTS WITH DIABETES-MELLITUS
复制标题
DOI：
10.1016/0026-0495(84)90197-5
复制
发表时间：
1984-01-01
影响因子：
9.8
通讯作者：
BIGLEY, R
中科院分区：
文献类型：
--
作者：
STANKOVA, L;RIDDLE, M;BIGLEY, R
与非糖尿病受试者相比，糖尿病患者血液粒细胞和单核细胞摄取脱氢抗坏血酸的速率较慢，血浆抗坏血酸浓度较低。这些测量值彼此之间或与同时测量的葡萄糖或糖化血红蛋白不相关;它们不因糖尿病类型或治疗模式而异。在那些糖尿病粒细胞表现出缓慢的脱氢抗坏血酸摄取，脱氢抗坏血酸，2-脱氧葡萄糖，和3-O-甲基葡萄糖的最大速度（Vmax）的运输速率降低，每个到相同的程度，而这些配体的运输Km值是没有不同的从那些观察到的nondiabetic细胞。由于这些配体的扩散是由一个共同的转运蛋白促进，这些观察结果可能反映了一些糖尿病白细胞质膜中葡萄糖转运蛋白的数量减少。
Rates of dehydroascorbate uptake by blood granulocytes and mononuclear cells are slower, and plasma ascorbate concentrations are lower, among persons with diabetes mellitus than in nondiabetic subjects. These measurements do not correlate with one another or with simultaneously measured glucose or glycosylated Hb; they do not differ with type of diabetes or mode of treatment. In those diabetic granulocytes that exhibit slow dehydroascorbate uptake, maximal velocity (Vmax) transport rates for dehydroascorbate, 2-deoxyglucose, and 3-O-methylglucose are decreased, each to the same degree, while Km values for transport of these ligands are not different from those observed in nondiabetic cells. Since diffusion of these ligands is facilitated by a common transporter, these observations may reflect decreased numbers of glucose transporters in the plasma membranes of some diabetic leukocytes.