Olfactory event-related potentials and aging: normative data
Olfactory event-related potentials and aging: normative data
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DOI：
10.1016/s0167-8760(99)00107-5
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发表时间：
2000-05-01
影响因子：
3
通讯作者：
Polich, JM
中科院分区：
文献类型：
--
作者：
Murphy, C;Morgan, CD;Polich, JM
与诱发电位的临床应用不同（例如，用于评估听觉功能的脑干听觉诱发电位），嗅觉事件相关电位（OERP）的规范性数据尚未获得。主要目的是建立一个给定的一组参数的OERPs在整个人类寿命的规范性数据。参与者是来自七个年龄组（16-19岁、20-29岁、30-39岁、40-49岁、50-59岁、60-69岁和70-79岁）的140人，其中男性和女性人数相等，接受鼻健康和痴呆症筛查。气味刺激物是乙酸戊酯，在鼻温下呈现在由空气稀释嗅觉计以恒定流速递送的加湿气流中，使用60-s刺激间隔。在Fz、Cz和Pz电极部位记录OERPs，放大并在试验中取平均值。分析N1/P2和P3的振幅以及P2和P3的振幅。处理速度在几十年内以恒定的速度下降的感觉（P2潜伏期）以及认知（P3潜伏期）组件。几十年来幅度的下降也很明显。规范性数据将有助于嗅觉功能的研究和嗅觉功能状态的临床评估。(C)2000由Elsevier Science B. V.出版，保留所有权利。
Unlike the clinical usages of evoked potentials (e.g. brain stem auditory evoked potentials for the assessment of auditory function), normative data for the olfactory event-related potential (OERP) have been unavailable. The principal objective was to establish normative data across the human life span for OERPs with a given set of parameters. Participants were 140 persons from seven age groups (16-19, 20-29, 30-39, 40-49, 50-59, 60-69 and 70-79 years of age), with equal numbers of males and females, screened for nasal health and dementia. The odor stimulus was amyl acetate, presented at nasal temperature in a humidified airstream delivered by an air-dilution olfactometer at a constant flow rate, using a 60-s inter-stimulus interval. OERPs were recorded at Fz, Cz, and Pz electrode sites, amplified and averaged over trials. Amplitudes of the N1/P2 and P3 and latencies of the P2 and P3 were analyzed. Processing speed decreased at a constant rate over decades for the sensory (P2 latency) as well as cognitive (P3 latency) components. Decline in amplitude over decades was also apparent. Normative data will be useful in research on olfactory function and in clinical assessment of olfactory functional status. (C) 2000 Published by Elsevier Science B.V. All rights reserved.