PATTERNS OF MATERNAL-BEHAVIOR IN THE SPONTANEOUSLY HYPERTENSIVE RAT
PATTERNS OF MATERNAL-BEHAVIOR IN THE SPONTANEOUSLY HYPERTENSIVE RAT
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DOI：
10.1016/0031-9384(87)90165-x
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发表时间：
1987-01-01
影响因子：
2.9
通讯作者：
MCCARTY, R
中科院分区：
文献类型：
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作者：
CIERPIAL, MA;SHASBY, DE;MCCARTY, R
在断奶前（第 1-21 天）评估自发性高血压 (SHR) 和 Wistar-Kyoto (WKY) 血压正常大鼠的母亲行为。使用扫描采样技术在光：暗循环的黑暗阶段观察每种菌株的十窝。全天定期观察笼子，并将大坝的瞬时行为记录在包含 9 种不同行为的清单上。这些行为包括：护理整窝幼崽、护理部分幼崽、接触整窝幼崽、接触部分幼崽、携带/取回幼崽、舔幼崽、嗅幼崽、筑巢和远离幼崽。在明暗周期的光照阶段以相同的方式观察第二组每株十窝幼崽，从而提供整个断奶前期间的全天候数据。出于数据分析的目的，21 天的断奶前阶段被分为 7-3 天的区块。分别确定每个区块和光：暗周期的每个阶段从 SHR 和 WKY 母亲观察到的每种行为的平均相对频率。在昼夜节律周期的浅色阶段，SHR 母亲比 WKY 母亲更频繁地与幼崽在一起并哺乳。与这一发现相辅相成的是，在白天和黑暗阶段，WKY 母亲比 SHR 母亲更频繁地远离幼崽。最后，观察到 SHR 母亲在光暗周期的两个阶段比 WKY 母亲更频繁地舔幼崽。这些发现在整个断奶前时期都是一致的。讨论了早期环境对 SHR 大鼠高血压发展的影响。
Maternal behavior of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive rats was assessed over the preweanling period (days 1-21). Ten litters of each strain were observed during the dark phase of the light:dark cycle using a scan sampling technique. Cages were observed periodically throughout the day and the momentary behavior of the dam was recorded on a checklist of 9 different behaviors. These behaviors included: nursing entire litter, nursing part of litter, contact with entire litter, contact with part of litter, pup carrying/retrieval, licking pups, sniffing pups, nest building, and away from litter. A second set of ten litters per strain was observed in the same manner during the light phase of the light:dark cycle thus providing around the clock data throughout the entire preweanling period. For purposes of data analysis, the 21-day preweanling period was divided into 7-3 day blocks. The mean relative frequency with which each behavior was observed from SHR and WKY mothers was determined for each block and for each phase of the light:dark cycle separately. SHR mothers were with their pups and nursing them more frequently than WKY mothers during the light phase of the circadian cycle. Complimentary to this finding, WKY mothers were observed away from their pups more frequently than SHR mothers during both light and dark phases. Finally, SHR mothers were observed to lick their pups more often than WKY mothers during both phases of the light:dark cycle. These findings were consistent across the entire preweanling period. The results are discussed in terms of early environmental influences on the development of hypertension in the SHR rat.