Influences of age, tongue region, and chorda tympani nerve sectioning on signal detection measures of lingual taste sensitivity
Influences of age, tongue region, and chorda tympani nerve sectioning on signal detection measures of lingual taste sensitivity
复制标题
DOI：
10.1016/j.physbeh.2015.12.014
复制
发表时间：
2016-03-01
影响因子：
2.9
通讯作者：
Bigelow, Douglas
中科院分区：
文献类型：
--
作者：
Doty, Richard L.;Heidt, Julie M.;Bigelow, Douglas
虽然味觉能力对摄入、营养和生活质量至关重要，但对于年龄、性别和鼓室索（CT）切除对舌前部不同区域味觉功能的影响，目前普遍缺乏清晰的认识。在这项研究中，我们采用无标准信号检测分析来评估不同年龄和性别的正常人以及单侧CT切除患者的多个舌头区域的电和化学味觉功能。受试者为33名健康志愿者，年龄18 ~ 87岁；9名单侧CT病变患者，年龄27 ~ 77岁。在16个舌区对弱电流和蔗糖、氯化钠和咖啡因溶液评估了年龄、性别、舌区和中耳索切除对信号检测灵敏度（d'）和反应偏差（beta）措施的影响。蔗糖（p = 0.012）、氯化钠（p = 0.002）、咖啡因（p = 0.006）和电流（EC） （p = 0.0001）的d'随年龄显著降低。对于大多数刺激，显著的从后到前，从内到外，表现梯度增加。在最年轻的实验对象中，在电刺激下，舌头的前部比后部大，而在最年长的实验对象中，蔗糖的情况正好相反。性别差异不明显。所有舌区均不同程度地在CT病变侧同侧凹陷，舌内侧和舌前部的影响最弱。这项研究首次采用信号检测分析来评估舌头对化学和电刺激的区域敏感性。它清楚地表明，舌头区域在与年龄相关的敏感性和对CT病变的易感性方面彼此不同。(C) 2015 Elsevier Inc .版权所有
5 Although the ability to taste is critical for ingestion, nutrition, and quality of life, a clear understanding of the influences of age, sex, and chorda tympani (CT) resection on taste function in different regions of the anterior tongue is generally lacking. In this study we employed criterion-free signal detection analysis to assess electric and chemical taste function on multiple tongue regions in normal individuals varying in age and sex and in patients with unilateral CT resections. The subjects were 33 healthy volunteers, ranging from 18 to 87 years of age, and 9 persons, 27 to 77 years of age, with unilateral CT lesions. The influences of age, sex, tongue region, and chorda tympani resections on signal detection sensitivity (d') and response bias (beta) measures was assessed in 16 tongue regions to weak electric currents and solutions of sucrose, sodium chloride, and caffeine. Significant age-related decrements in d' were found for sucrose (p = 0.012), sodium chloride (p = 0.002), caffeine (p = 0.006), and electric current (EC) (p = 0.0001). Significant posterior to anterior, and medial to lateral, gradients of increasing performance were present for most stimuli. beta was larger on the anterior than the posterior tongue for the electrical stimulus in the youngest subjects, whereas the opposite was true for sucrose in the oldest subjects. No sex differences were apparent. d' was depressed ipsilateral to the CT lesion side to varying degrees in all tongue regions, with the weakest influences occurring on the medial and anterior tongue. CT did not meaningfully influence This study is the first to employ signal detection analysis to assess the regional sensitivity of the tongue to chemical and electrical stimuli. It clearly demonstrates that tongue regions differ from one another in terms of their age-related sensitivity and their susceptibility to CT lesions. (C) 2015 Elsevier Inc All rights reserved.