Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer.
Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic cancer.
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DOI：
10.3892/or.16.3.457
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发表时间：
2006-09
期刊：
影响因子：
4.2
通讯作者：
Y. Oida;H. Yamazaki;K. Tobita;M. Mukai;Y. Ohtani;N. Miyazaki;Y. Abe;T. Imaizumi;H. Makuuchi;Y. Ueyama;Masato Nakamura
中科院分区：
文献类型：
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作者：
Y. Oida;H. Yamazaki;K. Tobita;M. Mukai;Y. Ohtani;N. Miyazaki;Y. Abe;T. Imaizumi;H. Makuuchi;Y. Ueyama;Masato Nakamura
钙结合蛋白S100A4与e -钙粘蛋白呈负相关，已知与多种癌症的预后相关。在本研究中，我们研究了S100A4和E-cadherin的表达与胰腺癌临床病理参数的关系。用免疫组织化学方法检测了72例原发性胰腺癌标本中这两种蛋白的表达情况。72例原发性胰腺癌手术标本中56例（78%）免疫组化S100A4阳性。31例（43%）胰腺癌标本显示E-cadherin阳性表达。S100A4与E-cadherin在肿瘤中的表达呈负相关（p < 0.0001）。S100A4表达与病理性T分期及预后不良相关（p = 0.024）。41例e -cadherin阴性患者预后较差，肝转移发生率较高（p = 0.0344, p = 0.027）。10例s100a4阴性/ e -cadherin阳性肿瘤预后明显优于其他肿瘤（p < 0.05）。组织学分级（p = 0.004）、淋巴结状态（p < 0.0001）和s100a4阳性状态（p = 0.048）是高度显著的独立预后预测因子（p < 0.05）。提示S100A4过表达与E-cadherin表达降低在胰腺癌的肿瘤进展和转移中起重要作用。这两种分子的联合检测有助于评估胰腺癌患者的预后。
The calcium-binding protein, S100A4, with an inverse association of E-cadherin, is known to correlate with prognosis in various cancers. In this study, we investigated the expression of the S100A4 and E-cadherin status in relation to the clinicopathological parameters of pancreatic cancer. The expression status of these two proteins was examined in 72 specimens of primary pancreatic carcinoma with immunohistochemistry. Fifty-six of 72 (78%) surgical specimens of primary pancreatic cancer were positive for S100A4 according to immunohistochemistry. Thirty-one (43%) specimens of pancreatic cancer showed positive expression of E-cadherin. The inverse association of S100A4 and E-cadherin expression was significant in the cancers (p < 0.0001). The S100A4 expression correlated significantly with the pathological T stage and poorer prognosis (p = 0.024). The 41 E-cadherin-negative cases showed poorer prognoses and a higher incidence of liver metastasis (p = 0.0344, p = 0.027). The 10 cases with S100A4-negative/E-cadherin-positive cancers showed a significantly better prognosis than the others (p < 0.05). The histological grade (p = 0.004), nodal status (p < 0.0001) and S100A4-positive status (p = 0.048) were highly significant independent prognostic predictors (p < 0.05). These results suggest that S100A4 overexpression combined with reduced E-cadherin expression play important roles in tumor progression and metastasis in pancreatic cancer. The combined examination of these two molecules is useful in evaluating the outcome of pancreatic cancer patient.