Sunlight exposure and risk of lens opacities in a population-based study -: The Salisbury Eye Evaluation Project
Sunlight exposure and risk of lens opacities in a population-based study -: The Salisbury Eye Evaluation Project
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DOI：
10.1001/jama.280.8.714
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发表时间：
1998-08-26
影响因子：
120.7
通讯作者：
Schein, OD
中科院分区：
文献类型：
--
作者：
West, SK;Duncan, DD;Schein, OD
上下文。-在阳光下暴露于UV-B辐射已被证明会增加高危职业人群白内障形成的风险，但对人群的风险尚未被量化。-测定老年人眼部在阳光下暴露于UV-B辐射的情况，并测定UV-B与晶状体混浊度之间的关系。-索尔兹伯里眼科评估项目，一个以人群为基础的老年人队列。索尔兹伯里,Md.Participants。- 1993年至1995年，马里兰州索尔兹伯里共有2520名65至84岁的社区居民，其中26.4%为非洲裔美国人。主要结果测量方法：在马里兰州太阳曝晒的年份中，至少一只眼有摄影记录的3/16或更大的皮质混浊与眼部UV-B暴露有关。-随着眼部暴露于UV-B的增加，皮质混浊的几率增加（优势比[OR]， 1.10； 95%可信区间[CI]， 1.02-1.20）。女性（OR, 1.14; 95% CI, 1.00-1.30）和非裔美国人（OR, 1.18; 95% CI, 1.04-1.33）的关系相似。对30岁以后各年龄组眼剂量的分析显示，无易感年龄组，提示损伤是基于累积暴露。-尽管美国老年人的眼部暴露在阳光下UV-B的几率相对较低，但眼部暴露与皮层混浊的几率增加之间仍然存在关联。我们的研究发现了非裔美国人之间的联系，据我们所知，这在以前没有报道过。所有性别和种族的人都能从避免眼部阳光照射的简单方法中受益。
Context.-Exposure to UV-B radiation in sunlight has been shown to increase the risk of cataract formation in high-risk occupational groups, but risk to the population has not been quantified.Objectives.-To determine the ocular exposure to UV-B radiation in sunlight for a population of older persons and to determine the association between UV-B and lens opacities.Design.-The Salisbury Eye Evaluation project, a population-based cohort of older adults.Setting.-Salisbury, Md.Participants.-A total of 2520 community-dwelling 65-year-old to 84-year-old adults in Salisbury, Md, from 1993 to 1995, of whom 26.4% were African Americans.Main Outcome Measure-Association of photographically documented cortical opacity 3/16 or greater in at least 1 eye with ocular UV-B exposure, reported in Maryland sun-years of exposure.Results.-The odds of cortical opacity increased with increasing ocular exposure to UV-B (odds ratio [OR], 1.10; 95% confidence interval [CI], 1.02-1.20). The relationship was similar for women (OR, 1.14; 95% CI, 1.00-1.30) and for African Americans (OR, 1.18; 95% CI, 1.04-1.33). Analyses of the ocular dose by each age group after the age of 30 years showed no vulnerable age group, suggesting damage is based on cumulative exposure.Conclusions.-Although this population of older Americans has relatively low ocular exposure to UV-B in sunlight, there is still an association between ocular exposure and increasing odds of cortical opacity. Our study found an association among African Americans, which, to our knowledge, has not been reported previously. All sex and racial groups would benefit from simple methods to avoid ocular sun exposure.