Human Polymerized Hemoglobin for the Treatment of Hemorrhagic Shock when Blood Is Unavailable: The USA Multicenter Trial
Human Polymerized Hemoglobin for the Treatment of Hemorrhagic Shock when Blood Is Unavailable: The USA Multicenter Trial
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DOI：
10.1016/j.jamcollsurg.2008.09.023
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发表时间：
2009-01-01
影响因子：
5.2
通讯作者：
Gould, Steven A.
中科院分区：
文献类型：
--
作者：
Moore, Ernest E.;Moore, Frederick A.;Gould, Steven A.
背景技术背景：人聚合血红蛋白（PolyHeme，Northfield Laboratories）是一种普遍相容的氧载体，用于治疗危及生命的贫血。这项多中心III期临床试验是美国第一项评估从受伤现场开始使用血红蛋白氧载体复苏患者生存率的研究。
BACKGROUND: Human polymerized hemoglobin (PolyHeme, Northfield Laboratories) is a universally compatible oxygen carrier developed to treat life-threatening anemia. This multicenter phase III trial was the first US study to assess Survival of patients resuscitated with a hemoglobin-based oxygen carrier starting at the scene of injurySTUDY DESIGN: Injured patients with a systolic blood pressure