Ethnic differences in triglyceride levels and high-density lipoprotein lead to underdiagnosis of the metabolic syndrome in black children and adults.
Ethnic differences in triglyceride levels and high-density lipoprotein lead to underdiagnosis of the metabolic syndrome in black children and adults.
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DOI：
10.1016/j.jpeds.2009.04.049
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发表时间：
2009-09
影响因子：
5.1
通讯作者：
Sumner, Anne E
中科院分区：
文献类型：
--
作者：
Sumner, Anne E
代谢综合征的目的是确定个人在高风险的发展2型糖尿病和心血管疾病。与白人相比，黑人患糖尿病和心血管疾病的比例更高。奇怪的是，黑人的代谢综合征患病率较低。根据国家胆固醇教育治疗计划-成人治疗小组III设定的标准，要诊断代谢综合征，必须存在5个特征中的3个。这些特征是低的高密度脂蛋白水平、增加的甘油三酯水平、中心性肥胖、高血压和空腹高血糖。单独检查这些因素，黑人比白人更容易患肥胖症，高血压和糖尿病。相比之下，黑人比白人更不可能有甘油三酯升高或低高密度脂蛋白水平。血脂水平的种族差异可能在很大程度上解释了为什么黑人的代谢综合征患病率低于预期。在这篇综述中，我们将描述在儿童和成人中与代谢综合征相关的疾病的流行病学研究中的种族差异，以及关注代谢综合征的每个参数。总体而言，我们得出结论，在代谢综合征的血脂标准的种族特异性配方可能会导致更好地识别黑人在发展糖尿病和心血管疾病的高风险。
The metabolic syndrome was designed to identify individuals at high risk for the development of type 2 diabetes and cardiovascular disease. Compared with whites, blacks have higher rates of diabetes and cardiovascular disease. Paradoxically, blacks have a lower prevalence of the metabolic syndrome. According to the criteria set by National Cholesterol Education Treatment Program–Adult Treatment Panel III, to diagnose the metabolic syndrome, 3 of 5 characteristics must be present. These characteristics are low high-density lipoprotein levels, increased triglyceride levels, central obesity, hypertension, and fasting hyperglycemia. Examining each of these factors individually, blacks are more likely than whites to have obesity, hypertension, and diabetes. In contrast, blacks are less likely than whites to have either elevated triglyceride or low high-density lipoprotein levels. Ethnic differences in lipid levels may largely explain why blacks have a lower than expected prevalence of the metabolic syndrome. In this review we will describe in children and adults ethnic differences in the epidemiologic study of conditions associated with the metabolic syndrome, as well as focus on each of the parameters of the metabolic syndrome. Overall, we conclude that an ethnic-specific formulation of the lipid criteria in the metabolic syndrome may lead to better identification of blacks at high risk for development of diabetes and cardiovascular disease.