Multiple system atrophy--the nature of the beast.
Multiple system atrophy--the nature of the beast.
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多系统萎缩——野兽的本性。
DOI：
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发表时间：
1989
影响因子：
11
通讯作者：
N. Quinn
中科院分区：
文献类型：
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作者：
N. Quinn
多系统萎缩 (MSA) 通常被认为是一种罕见疾病，但可能占帕金森病患者的 10%。全科医生、精神科医生、心脏病专家、自主神经专家、普通神经科医生以及那些对帕金森症（作者自己的观点）或小脑疾病特别感兴趣的人可能会看到这种疾病的众多名称，加上对其千变万化的表现的无知，可能是其认识不足和误诊的原因。在本文中，考虑了该病的病史和疾病分类学，并提出了临时诊断标准。讨论了辅助检查的有用性（或其他方面），并强调了当前治疗方法的缺点。与特发性帕金森病一样，根除该疾病的最终目标需要更好的诊断，以确定病因，从而开发出能够预防或阻止疾病进程的根本治疗方法。
Multiple system atrophy (MSA) is generally considered a rare disease, but may account for up to 10% of patients with Parkinsonism. The profusion of names for this disease, which may present to general physicians, psychiatrists, cardiologists, autonomic specialists, general neurologists and those with a special interest in Parkinsonism (this author's own perspective) or cerebellar disorders, together with ignorance of its protean manifestations, may account for its underrecognition and misdiagnosis. In this article, the history and nosology of the condition are considered, and provisional diagnostic criteria are advanced. The usefulness (or otherwise) of ancillary investigations is addressed, and the shortcomings of current methods of treatment are stressed. As with idiopathic Parkinson's disease, the ultimate goal of eradicating the disease entails better diagnosis in order to establish the cause, and thence to develop a radical treatment capable of preventing or arresting the disease process.