Development of silica-encapsulated silver nanoparticles as contrast agents intended for dual-energy mammography.
Development of silica-encapsulated silver nanoparticles as contrast agents intended for dual-energy mammography.
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二氧化硅封装的银纳米颗粒的开发是用于双能乳房X线摄影的对比剂。
DOI：
10.1007/s00330-015-4152-y
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发表时间：
2016-09
影响因子：
5.9
通讯作者：
Maidment AD
中科院分区：
文献类型：
--
作者：
Karunamuni R;Naha PC;Lau KC;Al-Zaki A;Popov AV;Delikatny EJ;Tsourkas A;Cormode DP;Maidment AD
双能（DE）乳房X光检查最近进入了临床。先前的理论和模型研究表明，对于该技术，银比碘提供了更大的对比度。我们的目标是在体内表征和评估最终用于 DE 乳腺 X 线摄影的原型银造影剂。原型银造影剂的合成过程分为三步：合成银核、二氧化硅封装和 PEG 涂层。然后将纳米颗粒注射到小鼠体内，以确定它们在各个器官中的积累、血液半衰期和双能对比。所有动物程序均得到机构动物护理和使用委员会的批准。纳米颗粒的最终直径经测量为 102 (± 9) nm。这些颗粒从血管循环中去除，半衰期为15分钟，并在富含巨噬细胞的器官（如肝脏、脾脏和淋巴结）中积累。与单能量图像相比，双能量减影技术将粒子的信号差噪比提高了 15.2 倍。这些纳米粒子对小鼠没有产生不良影响。银纳米粒子是双能 X 射线成像的有效造影剂。随着设计的进一步改进，银纳米粒子可能在乳腺癌筛查和诊断中发挥重要作用。
Dual-energy (DE) mammography has recently entered the clinic. Previous theoretical and phantom studies demonstrated that silver provides greater contrast than iodine for this technique. Our objective was to characterize and evaluate in vivo a prototype silver contrast agent ultimately intended for DE mammography. The prototype silver contrast agent was synthesized using a three-step process: synthesis of a silver core, silica encapsulation, and PEG coating. The nanoparticles were then injected into mice to determine their accumulation in various organs, blood half-life, and dual-energy contrast. All animal procedures were approved by the Institutional Animal Care and Use Committee. The final diameter of the nanoparticles was measured to be 102 (± 9) nm. The particles were removed from the vascular circulation with a half-life of 15 minutes, and accumulated in macrophage-rich organs such as the liver, spleen, and lymph nodes. Dual-energy subtraction techniques increased the signal difference-to-noise ratio of the particles by as much as a factor of 15.2 compared to the single-energy images. These nanoparticles produced no adverse effects in mice. Silver nanoparticles are an effective contrast agent for dual-energy x-ray imaging. With further design improvements, silver nanoparticles may prove valuable in breast cancer screening and diagnosis.