THE EPIDEMIOLOGY OF INTERSTITIAL LUNG-DISEASES
THE EPIDEMIOLOGY OF INTERSTITIAL LUNG-DISEASES
复制标题
DOI：
10.1164/ajrccm.150.4.7921471
复制
发表时间：
1994-10-01
影响因子：
24.7
通讯作者：
SOBONYA, RE
中科院分区：
文献类型：
--
作者：
COULTAS, DB;ZUMWALT, RE;SOBONYA, RE
关于一般人群中间质性肺病(ILDS)的发生，流行病学数据很少。为了描述ILDS的流行和发病率，1988年10月在新墨西哥州伯纳利洛县建立了ILDS患者的以人群为基础的登记。在1988年10月1日至1990年9月30日期间，所有18岁及以上的临床诊断为ILD的患者都是从医生转诊、出院诊断、组织病理学报告和死亡证明中确定的。此外，通过从510例尸检病例中筛选肺标本来确定临床前或未诊断病例的患病率。总共筛选了2936例转诊，其中8.8%是流行病例，6.9%是偶发病例。总体而言，男性的ILDS患病率(80.9/10万)比女性(67.2/10万)高20%。同样，ILDS的总体发病率在男性(31.5/10万/年)略高于女性(26.1/10万/年)。临床前或未确诊的ILDS在所有死亡病例中的估计患病率为1.8%。男女中最常见的诊断是肺纤维化和特发性肺纤维化，两者合计占男性ILD诊断的46.2%，女性的44.2%。我们的结论是，在一般人群中，ILDS的发生可能比先前基于选定人群的估计更常见，而且这些疾病可能经常没有被发现。
Little epidemiologic data are available on the occurrence of interstitial lung diseases (ILDs) in the general population. To describe the prevalence and incidence of ILDs a population-based registry of patients with ILDs was established in Bernalillo County, New Mexico in October 1988. All patients 18 yr of age and older who had a clinical diagnosis of an ILD were identified during the period 10/1/88 through 9/30/90 from physician referrals, hospital discharge diagnoses, histopathology reports, and death certificates. In addition, the prevalence of preclinical or undiagnosed cases was identified by screening lung specimens from 510 autopsy cases. A total of 2,936 referrals were screened; 8.8% were prevalent cases and 6.9% were incident cases. Overall, the prevalence of ILDs was 20% higher in males (80.9 per 100,000) than in females (67.2 per 100,000). Similarly the overall incidence of ILDs was slightly more common in males (31.5 per 100,000/year) than females (26.1 per 100,000/year). The estimated prevalence of preclinical or undiagnosed ILDs among all deaths was 1.8%. The most common incident diagnoses among both sexes were pulmonary fibrosis and idiopathic pulmonary fibrosis, together accounting for 46.2% of all ILD diagnoses in males and 44.2% in females. We conclude that the occurrence of ILDs in the general population may be more common than previous estimates based on selected populations, and these disorders may frequently be unrecognized.