Preoperative 4-Week Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Liver Volume and Facilitates Bariatric Surgery in Morbidly Obese Patients
Preoperative 4-Week Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Liver Volume and Facilitates Bariatric Surgery in Morbidly Obese Patients
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DOI：
10.1007/s11695-013-0942-y
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发表时间：
2013-11-01
期刊：
影响因子：
2.9
通讯作者：
Gugenheim, Jean
中科院分区：
文献类型：
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作者：
Iannelli, Antonio;Martini, Francesco;Gugenheim, Jean
非酒精性脂肪肝病 (NAFLD) 是肥胖患者中一种非常常见的疾病，可能导致肝脏肿大，进而损害腹腔镜减肥手术期间到达胃食管连接处的通道。补充 Omega-3 多不饱和脂肪酸 (Omega-3 PUFA) 已被证明可以减少营养性肝脂肪变性。本研究的目的是评估为期 4 周的口服 Omega-3 PUFA 补充剂对肝脏体积的影响。20 名病态肥胖患者在接受腹腔镜 Roux-en-Y 胃绕道术 (LRYGBP) 且没有任何饮食限制的情况下，口服 Omega-3 PUFA（每天 1,500 毫克）4 周。在基线和治疗结束时通过肝脏超声检查估计左肝叶的体积。手术外科医生主观评价进入胃食管连接处的困难程度。所有患者均完成了研究，并且没有副作用的报告。治疗后，左肝叶的平均体积从 598 +/- 97 减少 20 % 至 484 +/- 118 cm(3) (p = 0.002)。据报道，进入胃食管交界处的方法很简单，在所有病例中，手术外科医生都可以轻松牵开左肝叶。这项研究表明，为期 4 周的口服 Omega-3 PUFA 补充剂疗程可显着缩小肝脏大小，从而促进 LRYGBP。
Non-alcoholic fatty liver disease (NAFLD) is a very common condition among obese patients that may lead to the enlargement of the liver, that in turn impairs the access to the gastro-esophageal junction during laparoscopic bariatric surgery. Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) supplementation has been shown to reduce nutritional hepatic steatosis. The aim of this study was to assess the effects of a 4-week course of oral Omega-3 PUFAs supplementation on the volume of the liver.20 morbidly obese patients were administered oral Omega-3 PUFAs (1,500 mg daily) for 4 weeks before undergoing the laparoscopic Roux-en-Y gastric bypass (LRYGBP) without any dietary restriction. The volume of the left hepatic lobe was estimated by liver ultrasonography at baseline and at the end of treatment. The degree of difficulty to access the gastro-esophageal junction was appreciated subjectively by the operating surgeon.All patients completed the study and no side effect was reported. The mean volume of the left hepatic lobe decreased by 20 % from 598 +/- 97 to 484 +/- 118 cm(3) after the treatment (p = 0.002). The access to the gastro-esophageal junction was reported as simple, with easy retraction of the left hepatic lobe by the operating surgeon in all cases.This study demonstrates that a 4-week course of oral Omega-3 PUFAs supplementation results in a significant reduction in liver size that facilitates the LRYGBP.