The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans
The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans
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DOI：
10.1128/ec.3.4.1062-1065.2004
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发表时间：
2004-08-01
期刊：
影响因子：
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通讯作者：
Calderone, RA
中科院分区：
文献类型：
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作者：
Kruppa, M;Krom, BP;Calderone, RA
白色念珠菌菌丝形态发生的调节可以通过群体感应（quorum sensing， QS）进行。一种QS信号，法尼醇，在高密度生长过程中产生并抑制形态发生。然而，调控QS的信号转导通路尚不清楚。在这里，我们发现一个缺乏Chk1p但不缺乏Sln1p或Nik1p组氨酸激酶的白色念珠菌突变体在细胞悬浮和生物膜形成过程中对法尼醇的抑制作用都是不耐受的。本研究首次证实了双组分信号转导蛋白在真核生物QS中的作用。
Regulation of hyphal morphogenesis in Candida albicans can occur through quorum sensing (QS). A QS signal, farnesol, is produced during high-density growth and inhibits morphogenesis. However, the signal transduction pathway that regulates QS is unknown. Here, we show that a C albicans mutant lacking Chk1p but not either the Sln1p or the Nik1p histidine kinase is refractory to the inhibitory effect of farnesol both in cell suspension and during the formation of a biofilm. This study is the first to demonstrate a role for a two-component signal transduction protein in QS by a eukaryotic organism.