Relaxant effect of propofol on the airway in dogs.
Relaxant effect of propofol on the airway in dogs.
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异丙酚对狗气道的松弛作用。
DOI：
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发表时间：
1997
影响因子：
9.8
通讯作者：
Akitomo Matsuki
中科院分区：
文献类型：
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作者：
K. Hirota;Tetsumi Sato;Y. Hashimoto;E. Hashiba;Tsuyoshi Kudo;Hironori Ishihara;Akitomo Matsuki
异丙酚已被建议在体内产生气道松弛作用，尽管其机制尚不清楚。我们采用超细纤维支气管镜直接观察的方法评估了异丙酚的支气管扩张效果。研究了21只戊巴比妥30 mg kg-1静脉麻醉和泮库溴铵0.2 mg kg-1 h-1麻醉的杂种狗。随机分为三组（每组7只）：异丙酚组、阿托品-异丙酚组和组胺-异丙酚组。气管插管使用气管管，气管管有第二个管腔，用于插入支气管镜，连续监测支气管横截面积（BCA）。使用NIH图像程序测量BCA。异丙酚组每隔10 min给药0（生理盐水）、0.2、2.0、20 mg kg-1静脉滴注。阿托品-异丙酚组每隔10 min给药生理盐水、阿托品0.2 mg kg-1、异丙酚20 mg kg-1。组胺-异丙酚组以组胺10 μ g kg-1和500 μ g kg-1 h-1诱导支气管收缩，直至实验结束。组胺开始输注30分钟后，给予异丙酚（0、0.2、2.0、20 mg kg-1）。BCA的变化以基底面积的百分比表示。组胺降低BCA 39.2% （SEM 5.4%）。异丙酚在20mg kg-1静脉注射后显著增加基础BCA和组胺降低BCA，剂量依赖性分别为18.4（4.5%）和15.8（4.9%）。然而，异丙酚在阿托品静脉注射后并没有增加BCA(阿托品静脉注射后129.9 （8.2)% vs丙泊酚静脉注射后125.7(8.9)%）。因此，异丙酚的松弛作用可能是迷走神经张力降低的结果。
Propofol has been suggested to produce airway relaxant effects in vivo, although the mechanism is unclear. We have evaluated the bronchodilating effect of propofol using a direct visualization method with a superfine fibreoptic bronchoscope. We studied 21 mongrel dogs anaesthetized with pentobarbital 30 mg kg-1 i.v. and pancuronium 0.2 mg kg-1 h-1. The animals were allocated randomly to one of three groups (n = 7 in each): propofol group, atropine-propofol group and histamine-propofol group. The trachea was intubated using a tracheal tube that had a second lumen for insertion of the bronchoscope to monitor continuously bronchial cross-sectional area (BCA). BCA was measured using the NIH Image program. In the propofol group, dogs were given the following doses of propofol at 10-min intervals: 0 (saline), 0.2, 2.0 and 20 mg kg-1 i.v. In the atropine-propofol group, saline, atropine 0.2 mg kg-1 and propofol 20 mg kg-1 were given at 10-min intervals. In the histamine-propofol group, bronchoconstriction was elicited with histamine 10 micrograms kg-1 and 500 micrograms kg-1 h-1 until the end of the experiment. Thirty minutes after the start of infusion of histamine, propofol (0, 0.2, 2.0 and 20 mg kg-1) was administered. Changes in BCA were expressed as percentage of basal area. Histamine decreased BCA by 39.2 (SEM 5.4%). Propofol increased significantly basal and histamine-decreased BCA in a dose-dependent manner by 18.4 (4.5%) and 15.8 (4.9%), respectively after 20 mg kg-1 i.v. However, propofol following atropine i.v. did not increase BCA (129.9 (8.2)% after atropine vs 125.7 (8.9)% after propofol). Therefore, the relaxant effect of propofol may be a result of reduction in vagal tone.
巴森吉灰狗哮喘模型：阿托品对抗原诱导的支气管收缩的影响。
DOI：
10.1152/jappl.1981.50.4.761
发表时间：
1981
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
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作者：
Hirshman,CA;Downes,H
通讯作者：
Downes,H