Progression from Feature-Specific Brain Activity to Hippocampal Binding during Episodic Encoding
Progression from Feature-Specific Brain Activity to Hippocampal Binding during Episodic Encoding
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DOI：
10.1523/jneurosci.1971-19.2019
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发表时间：
2020-02-19
影响因子：
5.3
通讯作者：
Ritchey, Maureen
中科院分区：
文献类型：
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作者：
Cooper, Rose A.;Ritchey, Maureen
情景记忆的特点是回忆与特定时空背景相关的多个感知细节。因此，为了记住一个事件，有必要在初始编码过程中将这些细节整合到一个连贯的表示中。在这里，我们测试了大脑如何并行编码和绑定多种不同类型的特征，以及这个过程如何在事件本身期间随着时间的推移而演变。我们分析了来自27名人类受试者（16名女性，11名男性）的数据，他们学习了一系列与颜色，全景场景位置和情感声音相关的物体，同时收集了功能磁共振成像数据。通过模拟大脑活动如何与即将到来或刚刚看到的信息的记忆相关，我们能够测试个体特征的神经特征以及整合事件在编码过程中的变化。我们观察到早期和晚期编码过程之间的显著分离：事件发生时的左下额叶和视觉感知信号跟踪随后回忆的细节量，并且基于不同的记忆特征而分离。与此相反，记忆相关的大脑活动在事件结束时转移到左侧海马体，这对将物品颜色和声音与空间信息联系起来特别敏感。这些结果提供了证据，早期，同时功能特定的神经反应，在情节编码，预测以后的记忆，并建议海马整合这些功能到一个连贯的经验，在事件过渡。
The hallmark of episodic memory is recollecting multiple perceptual details tied to a specific spatial-temporal context. To remember an event, it is therefore necessary to integrate such details into a coherent representation during initial encoding. Here we tested how the brain encodes and binds multiple, distinct kinds of features in parallel, and how this process evolves over time during the event itself. We analyzed data from 27 human subjects (16 females, 11 males) who learned a series of objects uniquely associated with a color, a panoramic scene location, and an emotional sound while fMRI data were collected. By modeling how brain activity relates to memory for upcoming or just-viewed information, we were able to test how the neural signatures of individual features as well as the integrated event changed over the course of encoding. We observed a striking dissociation between early and late encoding processes: left inferior frontal and visuo-perceptual signals at the onset of an event tracked the amount of detail subsequently recalled and were dissociable based on distinct remembered features. In contrast, memory-related brain activity shifted to the left hippocampus toward the end of an event, which was particularly sensitive to binding item color and sound associations with spatial information. These results provide evidence of early, simultaneous feature-specific neural responses during episodic encoding that predict later remembering and suggest that the hippocampus integrates these features into a coherent experience at an event transition.