Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations
Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations
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DOI：
10.1016/j.jdiacomp.2009.01.004
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发表时间：
2010-03-01
影响因子：
3
通讯作者：
Paolisso, Giuseppe
中科院分区：
文献类型：
--
作者：
Marfella, Raffaele;Barbieri, Michelangela;Paolisso, Giuseppe
越来越多的证据表明，血糖紊乱，如每日血糖快速波动可能在糖尿病并发症中起重要作用。我们评估了西格列汀100 mg每日一次与维格列汀50 mg每日两次对二甲双胍控制不佳的2型糖尿病患者每日血糖波动的疗效。在接受二甲双胍+维格列汀（n=18）或西格列汀（n=20）治疗3个月的患者中进行了48小时连续皮下血糖监测（CSGM）。血糖波动的平均幅度（法师）用于评估白天的血糖波动。在标准餐期间，测量胰高血糖素样肽-1（GLP-1）、胰高血糖素和胰岛素。CSGM显示，与西格列汀组相比，维达戈肽组的法师降低幅度较大（P
There is increasing evidence that glycemic disorders such as rapid glucose fluctuations over a daily period might play an important role on diabetic complications. We evaluated the efficacy of sitagliptin 100 mg once daily vs. vildagliptin 50 mg twice daily on daily blood glucose fluctuations in patients with type 2 diabetes that was inadequately controlled by metformin. Forty-eight-hour continuous subcutaneous glucose monitoring (CSGM) was performed in patients treated with metformin plus vildagliptin (n=18) or sitagliptin (n=20) over a period of 3 months. The mean amplitude of glycemic excursions (MAGE) was used for assessing glucose fluctuations during the day. During a standardized meal, glucagon-like peptide-1 (GLP-1), glucagon, and insulin were measured. CSGM shows large MAGE decrements in the vildagliptin group compared with the sitagliptin group (P