Roles of TGFβ and BMP during valvulo–septal endocardial cushion formation
Roles of TGFβ and BMP during valvulo–septal endocardial cushion formation
复制标题
DOI：
10.1007/s12565-009-0027-0
复制
发表时间：
2009-03
影响因子：
1.2
通讯作者：
T. Yamagishi;Katsumi Ando;Hiroaki Nakamura
中科院分区：
文献类型：
--
作者：
T. Yamagishi;Katsumi Ando;Hiroaki Nakamura
瓣膜原基和房室间隔起源于心脏发生过程中流出道(OFT)和房室(AV)区域形成的心内膜垫组织。心内膜垫发育异常可导致各种先天性心脏病。心内膜上皮-间充质转化(EMT)是缓冲组织形成的关键过程，受多种因素调控，如生长因子、细胞间信号分子、转录因子和细胞外基质等。由房室和OFT区域的心肌产生并通过细胞外基质传递到相邻心内膜的信号是EMT的媒介。体外研究和遗传分析表明，转化生长因子β和骨形态发生蛋白在缓冲组织形成过程中对内皮细胞转化的调控起着核心作用。
The primordia of valves and the atrioventricular septum arise from endocardial cushion tissue that is formed in the outflow tract (OFT) and in the atrioventricular (AV) regions during cardiogenesis. Abnormal development of the endocardial cushion results in various congenital heart diseases. Endocardial epithelial–mesenchymal transformation (EMT) is a critical process in cushion tissue formation and is regulated by many factors, such as growth factors, intercellular signaling molecules, transcription factors, and extracellular matrices. A signal that is produced by the myocardium of the AV and OFT regions and transferred to the adjacent endocardium across the extracellular matrix mediates EMT. Studies in vitro and genetic analyses have shown that transforming growth factor β and bone morphogenetic protein play central roles in the regulation of EMT during cushion tissue formation.