Oral choline increases choline metabolites in human brain
Oral choline increases choline metabolites in human brain
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DOI：
10.1016/s0925-4927(03)00104-5
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发表时间：
2004-01-15
影响因子：
2.3
通讯作者：
Cohen, BM
中科院分区：
文献类型：
--
作者：
Babb, SM;Ke, Y;Cohen, BM
胆碱是乙酰胆碱和磷脂酰胆碱的前体，主要从饮食中获得。动物研究表明，口服给药后脑内胆碱代谢物增加。几个质子磁共振波谱（H-1-MRS）报告对于是否在人类受试者中观察到类似的增加有所不同。本研究旨在最大限度地减少受试者内部差异，从而最大限度地确定胆碱摄入后是否可以检测到脑胆碱显著增加。11名健康年轻男性在摄入胆碱后连续2.5 h进行h -1- mrs检测。原来的9名受试者在没有摄入胆碱的情况下进行了相同的扫描。口服胆碱后，从左壳核测量的胆碱信号（Cho）有统计学显著增加，代表含胆碱化合物，与肌酸（Cr）或n -乙酰天冬氨酸（NAA）相比。Cho/Cr和Cho/NAA的曲线最大值（C-max）的平均增幅分别为6.2%和3.0%。平均到达C-max时间（T-max）约为摄入后2小时。MRS对Cho的3-6%的增加可能对应于磷脂胆碱的10-22%的增加，这与动物研究的结果相似。综上所述，青年人摄入胆碱后，H-1-MRS可以检测到人脑中含胆碱化合物的显著增加。2003爱思唯尔爱尔兰有限公司版权所有。
Choline, a precursor of acetylcholine and phosphatidylcholine, is largely obtained from the diet. Animal studies demonstrate increased choline metabolites in brain following oral administration. Several proton magnetic resonance spectroscopy (H-1-MRS) reports differ as to whether similar increases are observable in human subjects. This study was designed to minimize intra-subject variance and thereby maximize the ability to determine if a significant increase in brain choline can be detected after choline ingestion. H-1-MRS was performed continuously for 2.5 h on 11 healthy young males following choline ingestion. Nine of the original subjects returned for identical scans without choline ingestion. Following oral choline, there was a statistically significant increase in the choline signal (Cho) measured from the left putamen, representing choline-containing compounds, as measured against creatine (Cr) or N-acetylaspartate (NAA). The mean increase in Curve maxima (C-max) is 6.2% for Cho/Cr and 3.0% for Cho/NAA. The Mean Time to C-max (T-max) was approximately 2 h after ingestion. A 3-6% increase in Cho by MRS likely corresponds to a 10-22% increase in phosphocholine, similar to findings in animal studies. In conclusion, a significant increase in choline-containing compounds in human brain can be detected by H-1-MRS after choline ingestion in young subjects. (C) 2003 Elsevier Ireland Ltd. All rights reserved.