Poly(Piloty's acid): a slow releasing macromolecular HNO donor
Poly(Piloty's acid): a slow releasing macromolecular HNO donor
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DOI：
10.1039/d2py01339h
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发表时间：
2023-05-15
影响因子：
4.6
通讯作者：
Matson，John B.
中科院分区：
文献类型：
--
作者：
Swilley，Sarah N.;Zajkowski，Evan M.;Matson，John B.
我们报道了一种Piloty酸的聚合物版本，其中HNO的释放速率可以通过改变嵌段共聚体系中聚乙二醇b-聚(Piloty酸)的嵌段比例来调节。聚Piloty‘s酸嵌段是由聚苯磺酸盐衍生而来的，嵌段共聚物的HNO释放量随聚Piloty’s酸嵌段长度的增加而变化一个数量级。我们预计这项研究将指导HNO释放聚合物的开发，以测量HNO在生物系统中持续释放的效果。
We report a polymeric version of Piloty's acid where the release rate of HNO can be tuned by changing the block ratios of PEG-b-poly(Piloty's acid) in a block copolymer system. The poly(Piloty's acid) block was derived from poly(styrene sulfonate), and HNO release from the block copolymers varied by as much as an order of magnitude via increasing the length of the poly(Piloty's acid) block. We anticipate this study will guide the development of HNO-releasing polymers to measure the effects of sustained HNO delivery in biological systems.