Full-frequency correction of spatial impulse response in back-projection scheme using space-variant filtering for optoacoustic mesoscopy
Full-frequency correction of spatial impulse response in back-projection scheme using space-variant filtering for optoacoustic mesoscopy
复制标题
使用空变滤波光声介观法对反投影方案中的空间脉冲响应进行全频校正
DOI：
10.1016/j.pacs.2020.100193
复制
发表时间：
2020-09-01
期刊：
影响因子：
7.9
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
--
作者：
Lu, Tong;Wang, Yihan;Ntziachristos, Vasilis
将聚焦换能器的空间脉冲响应(SIR)考虑到重建中，可以显著提高光声介观(OPAM)重建图像的保真度和重建质量。然而，传统的完全考虑SIR的方法由于内存和时间消耗过大，很难满足高分辨率OAM对数据密集型的要求。本文提出了一种改进的空间变滤波反投影法用于SIR的全频校正，并将其应用于球面聚焦换能器的OPAM系统。该方法可以方便地管理OPAM的大数据集，并有效地减少额外的时间消耗。通过对人体模型和生物组织的仿真和实验，验证了该方法的有效性。结果表明，改进的反投影法在图像保真度、分辨率和对比度等方面均优于未考虑或不完全考虑SIR的常规反投影法和加权反投影法。
The fidelity and quality of reconstructed images in optoacoustic mesoscopy (OPAM) can be significantly improved by considering the spatial impulse response (SIR) of the employed focused transducer into reconstruction. However, the traditional method fully taking the SIR into account can hardly meet the data-intensive requirements of high resolution OPAM because of excessive memory and time consumption. Herein, a modified back-projection method using a space-variant filter for full-frequency correction of the SIR is presented, and applied to the OPAM system with a sphere-focused transducer. The proposed method can readily manage the large datasets of the OPAM and effectively reduce the extra time consumption. The performance of the proposed method is showcased by simulations and experiments of phantoms and biological tissue. The results demonstrate that the modified back-projection method exhibits better image fidelity, resolution and contrast compared to the common and weighted back-projection methods that are not or not fully accounting for the SIR.