The multi-step nature of carcinogenesis and the implications for risk analysis
The multi-step nature of carcinogenesis and the implications for risk analysis
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DOI：
10.1080/095530098142194
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发表时间：
1998-04-01
影响因子：
2.6
通讯作者：
Cox, R
中科院分区：
文献类型：
--
作者：
Cox, R
目的：为了构建辐射致癌风险的生物学模型，有必要对辐射后的机制有详细的了解。方法：本文简要回顾了DNA损伤反应、肿瘤发生/发展的某些方面及其伴随因素，并对辐射致癌风险评估的意义和仍然存在的一些不确定性进行了评论。结论：根据动物模型的研究，辐射肿瘤的发生主要是在辐射诱导的单靶干细胞特异性基因丢失之后以传统的多步骤方式进行的。
Purpose: For the purposes of constructing biologically realistic models of radiation cancer risk it is necessary to have detailed knowledge of the post-irradiation mechanisms involved.Methods: This brief review considers selected aspects of DNA damage response, tumour initiation/development, together with attendant factors and provides comment on the implications for cancer risk estimation and some of the uncertainties that remain.Conclusions: It is judged from studies with animal models that, in the main, radiation tumorigenesis proceeds in a conventional multi-step fashion following radiation-induced specific gene losses from single-target stem cells.