Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy
Nitric Oxide and Tumors: From Small-Molecule Donor to Combination Therapy
复制标题
DOI：
10.1021/acsbiomaterials.2c01247
复制
发表时间：
2022-12-28
影响因子：
5.8
通讯作者：
Sun, Taolei
中科院分区：
文献类型：
--
作者：
Huang, Wan;Zhang, Jun;Sun, Taolei
一氧化氮（NO）作为一种重要的内源性信号分子，参与生物体的多种生理和病理活动。NO在肿瘤治疗中发挥着重要作用，但其半衰期短、分布不特异等特点限制了其进一步的临床应用。因此，在过去的几十年里，我们已经看到了克服这些缺点所取得的进展，包括开发创新的NO供体，特别是智能和多模态纳米平台。这些平台可以精确地控制治疗药物在生物体内的时空分布，从而在肿瘤治疗中产生巨大差异。本文综述了目前NO治疗肿瘤的机制、从小分子到智能响应纳米药物递送平台的NO供体以及基于NO的联合治疗，强调了这些领域的突出突破，并希望为基于NO的肿瘤治疗带来新的见解。
As an important endogenous signaling molecule, nitric oxide (NO) is involved in various physiological and pathological activities in living organisms. It is proved that NO plays a critical role in tumor therapy, while the extremely short half-life and nonspecific distribution of NO greatly limit its further clinical applications. Thus, the past few decades have witnessed the progress made in conquering these shortcomings, including developing innovative NO donors, especially smart and multi modal nanoplatforms. These platforms can precisely control the spatiotemporal distribution of therapeutic agents in the organism, which make big differences in tumor treatment. Here current NO therapeutic mechanisms for cancer, NO donors from small molecules to smart-responsive nanodrug delivery platforms, and NO based combination therapy are comprehensively reviewed, emphasizing outstanding breakthroughs in these fields and hoping to bring new insights into NO-based tumor treatments.