Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord
Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord
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DOI：
10.1016/j.biomaterials.2005.11.015
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发表时间：
2006-04-01
期刊：
影响因子：
14
通讯作者：
Shoichet, MS
中科院分区：
文献类型：
--
作者：
Gupta, D;Tator, CH;Shoichet, MS
脊髓损伤修复的策略受到限制，部分原因是药物输送技术不佳。我们实验室正在开发一种新的药物递送系统（DDS），它可以从注射凝胶中局部释放生长因子。凝胶必须是快速胶凝的、非细胞粘附的、可降解的和生物相容的，作为可注射的鞘内DDS。符合这些设计标准的凝胶是透明质酸和甲基纤维素（HAMC）的混合物。与其他可注射凝胶不同，HAMC在注射前已经处于胶凝点。由于其剪切稀化特性，它是可注射的，并且其凝胶强度随着温度而增加。大鼠体内研究表明，HAMC在鞘内空间内具有生物相容性1个月，并且可以在行为方面提供治疗益处，如通过Basso，Beattie和Bresnahan（BBB）运动量表和炎症所测量的。这些数据表明，HAMC是一种有前途的凝胶局部输送治疗剂到受伤的脊髓。(c)2005爱思唯尔有限公司保留所有权利。
Strategies for spinal cord injury repair are limited, in part, by poor drug delivery techniques. A novel drug delivery system (DDS) is being developed in our laboratory that can provide localized release of growth factors from an injectable gel. The gel must be fast-gelling, non-cell adhesive, degradable, and biocompatible as an injectable intrathecal DDS. A gel that meets these design criteria is a blend of hyaluronan and methylcellulose (HAMC). Unlike other injectable gels, HAMC is already at the gelation point prior to injection. It is injectable due to its shear-thinning property, and its get strength increases with temperature. In vivo rat studies show that HAMC is biocompatible within the intrathecal space for 1 month, and may provide therapeutic benefit, in terms of behavior, as measured by the Basso, Beattie and Bresnahan (BBB) locomotor scale, and inflammation. These data suggest that HAMC is a promising gel for localized delivery of therapeutic agents to the injured spinal cord. (c) 2005 Elsevier Ltd. All rights reserved.