Stimulation of growth by intravenous injection of copper in weanling pigs.
Stimulation of growth by intravenous injection of copper in weanling pigs.
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DOI：
10.2527/1994.7292395x
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发表时间：
1994-09
影响因子：
3.3
通讯作者：
W. Zhou;E. Kornegay;M. Lindemann;J. Swinkels;M. Welten;E. Wong
中科院分区：
文献类型：
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作者：
W. Zhou;E. Kornegay;M. Lindemann;J. Swinkels;M. Welten;E. Wong
本研究旨在探讨铜在注射时是否能发挥促进生长的作用，而不是喂饲，从而绕过胃肠道。在两个为期18天的实验中，每隔2天给猪注射组氨酸或组氨酸铜溶液。计算了铜的注入量，以模拟饲喂250ppm饲料铜的猪的不同吸收率。在实验中1.将44头猪随机分为4组，每组11头。给猪注射四个水平的组氨酸铜(根据计算的饲料摄入量估计表观吸收系数为0、5、10和15%)。平均日增重与组氨酸铜水平呈二次曲线关系(P<；0.05)；5%组的日增重最大。在d6，血清促有丝分裂活性也表现出类似的二次反应(P<；0.05)。在实验中2、测定了0、2、4、6和8%的铜吸收率。将45头猪随机分成5组，每组9头，按实验方法注射。1.ADG和血清有丝分裂活性均呈二次曲线反应(P<；0.05)，以4%组反应最大。肝脏铜含量、超氧化物歧化酶活性和血清铜浓度均随铜剂量的增加而线性增加(P<；0.05)。脑内铜含量随铜剂量的增加呈线性增加(P<；0.05)。1和2。此外，实验组脑组织中铜激素的mRNA浓度。2不受处理的显著影响。(摘要截短250字)
This study was conducted to examine whether Cu could exert its growth-promoting effect when injected, rather than being fed, and thus bypass the gastrointestinal tract. In two 18-d experiments, pigs were injected every 2 d with a Cu histidinate or histidine solution. Amounts of Cu injected were calculated to simulate varying absorption rates in pigs fed 250 ppm of dietary Cu. In Exp. 1, 44 pigs were randomly assigned to four groups of 11 pigs each. Pigs were injected with four levels of Cu histidinate (0, 5, 10, and 15% estimated apparent absorption coefficients based on calculated feed intake). Average daily gain responded quadratically (P < .05) to levels of Cu histidinate; maximum growth was seen in the 5% group. At d 6, serum mitogenic activity also exhibited a similar quadratic response (P < .05). In Exp. 2, estimated Cu absorptions of 0, 2, 4, 6, and 8% were tested. Forty-five pigs were randomly assigned to five groups of nine pigs each and injected as in Exp. 1. Both ADG and serum mitogenic activity displayed a quadratic response (P < .05); the maximum response was seen in the 4% group. Liver Cu content, superoxide dismutase activity, and serum Cu concentrations were linearly increased (P < .05) with increasing dosage of Cu in both Exp. 1 and 2. Also, brain Cu content linearly increased (P < .05) with increasing dosage of Cu in both Exp. 1 and 2. Also, brain Cu hormone mRNA concentrations in Exp. 2 were not significantly influenced by treatments.(ABSTRACT TRUNCATED AT 250 WORDS)