Parathyroid tumors and related disorders
Parathyroid tumors and related disorders
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DOI：
10.1038/modpathol.2010.132
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发表时间：
2011-04-01
期刊：
影响因子：
7.5
通讯作者：
DeLellis, Ronald A.
中科院分区：
文献类型：
--
作者：
DeLellis, Ronald A.
原发性甲状旁腺功能亢进（P-HPT）是一种常见的内分泌疾病，由甲状旁腺腺瘤（80-85%）、增生（10-15%）或癌（< 1%）引起。遗传性P-HPT综合征的分子遗传学分析为了解散发性甲状旁腺肿瘤和增生提供了相当多的见解。这篇综述将集中在甲状旁腺增生性疾病的分类标准，并将突出我们在分子水平上对这些病变的理解。放射成像技术的进展，连同快速术中甲状旁腺激素测定将审查目前的治疗方法P-HPT。现代病理学（2011）24，S78-S93; doi：10.1038/modpathol.2010.132
Primary hyperparathyroidism (P-HPT) is a common endocrine disorder that occurs as a result of adenomas (80-85%), hyperplasias (10-15%) or carcinomas (< 1%) of the parathyroid glands. Molecular genetic analyses of heritable P-HPT syndromes have provided considerable insight into the understanding of sporadic parathyroid tumors and hyperplasias. This review will focus on the criteria for classification of parathyroid proliferative disorders and will highlight our understanding of these lesions at the molecular level. Advances in radiological imaging techniques together with the rapid intraoperative parathyroid hormone assay will be reviewed with respect to current treatment approaches for P-HPT. Modern Pathology (2011) 24, S78-S93; doi:10.1038/modpathol.2010.132